SLUG 抗体 (AA 5-120) (Biotin)
-
- 抗原 See all SLUG products
- SLUG
-
抗原表位
- AA 5-120
-
适用
- 人, 大鼠, 兔
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This SLUG antibody is conjugated to Biotin
-
应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 人, 兔, 大鼠
- 预测反应
- Mouse,Dog,Cow,Pig,Chicken
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human Slug
- 亚型
- IgG
-
anti-SLUG (AA 98-129) antibody
适用: 人, 大鼠, 小鼠 WB, IHC (p), IF 宿主: 兔 Polyclonal RB01398 unconjugated
anti-SLUG (AA 5-120) antibody适用: 人, 大鼠, 兔 WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SLUG antibody适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-SLUG (AA 1-30), (N-Term) antibody适用: 人 WB 宿主: 兔 Polyclonal RB15389 unconjugated
anti-SLUG (Middle Region 2) antibody适用: 人, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
-
- 抗原
- SLUG
- Abstract
- SLUG 产品
- 别名
- Slug antibody, Slugh antibody, Snail2 antibody, SLUG antibody, SLUGH antibody, SLUGH1 antibody, SNAIL2 antibody, WS2D antibody, snail family zinc finger 2 antibody, snail family transcriptional repressor 2 antibody, Snai2 antibody, SNAI2 antibody
- 背景
-
Synonyms: SLUG, WS2D, SLUGH1, SNAIL2, Zinc finger protein SNAI2, Neural crest transcription factor Slug, Protein snail homolog 2, SNAI2, SLUGH
Background: Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.
- 基因ID
- 6591
- UniProt
- O43623
-
