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Lipocalin 2 抗体 (AA 101-198)

LCN2 适用: 人 ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN685627
发货至: 中国
  • 抗原 See all Lipocalin 2 (LCN2) 抗体
    Lipocalin 2 (LCN2)
    抗原表位
    • 15
    • 13
    • 13
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 101-198
    适用
    • 98
    • 33
    • 28
    • 7
    • 5
    • 1
    • 1
    宿主
    • 92
    • 45
    • 6
    • 3
    • 3
    • 1
    克隆类型
    • 94
    • 56
    多克隆
    标记
    • 66
    • 25
    • 12
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Lipocalin 2 antibody is un-conjugated
    应用范围
    • 69
    • 62
    • 43
    • 17
    • 13
    • 13
    • 13
    • 12
    • 12
    • 10
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    交叉反应
    预测反应
    Mouse,Rat,Dog,Cow,Pig,Rabbit
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human Lipocalin 2
    亚型
    IgG
    Top Product
    Discover our top product LCN2 Primary Antibody
  • 应用备注
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • Xu, Zhang, Cheng, Liu, Zou, Zhan, Xiao, Xia: "Transcription factor 7-like 1 dysregulates keratinocyte differentiation through upregulating lipocalin 2." in: Cell death discovery, Vol. 2, pp. 16028, (2016) (PubMed).

    Xing, Wang, Cheng, Montaner, Mandeville, Leung, van Leyen, Lok, Wang, Lo: "Neuronal production of lipocalin-2 as a help-me signal for glial activation." in: Stroke; a journal of cerebral circulation, Vol. 45, Issue 7, pp. 2085-92, (2014) (PubMed).

  • 抗原
    Lipocalin 2 (LCN2)
    别名
    Lipocalin 2 (LCN2 产品)
    别名
    LCN2 antibody, 24p3 antibody, MSFI antibody, NGAL antibody, AW212229 antibody, Sip24 antibody, lipocalin 2 antibody, LCN2 antibody, Lcn2 antibody
    背景

    Synonyms: 24p3, MSFI, NGAL, Neutrophil gelatinase-associated lipocalin, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, Lipocalin-2, Oncogene 24p3, Siderocalin LCN2, p25, LCN2, HNL

    Background: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

    基因ID
    3934
    UniProt
    P80188
    途径
    Cellular Response to Molecule of Bacterial Origin, Transition Metal Ion Homeostasis
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