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IRF7 抗体 (AA 401-503)

Name: IRF7 抗体 (AA 401-503)
SKU: ABIN682603
Availability: OutOfStock

IRF7 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-IRF7 Polyclonal Antibody, Unconjugated (ABIN682603) at 1:200 followed by conjugation to the secondary antibody and DAB staining. (IRF7 抗体 (AA 401-503))

IHC

Paraformaldehyde-fixed, paraffin embedded rat brain tissue, Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with Rabbit Anti-IRF7 Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining (IRF7 抗体 (AA 401-503))

IHC (p)

Paraformaldehyde-fixed, paraffin embedded rat lung tissue, Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with Rabbit Anti-IRF7 Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining (IRF7 抗体 (AA 401-503))

IHC (p)

3 images

(3 references)

产品编号 ABIN682603

发货至: 中国

Datasheet as PDF

抗原 See all IRF7 抗体

IRF7 (Interferon Regulatory Factor 7 (IRF7))
抗原表位
16

16

14

8

5

3

2

2

1

1

1

1

1

1

1

1
AA 401-503
适用
66

54

53

16

8

3

2

2

1
人, 小鼠, 大鼠, Pig
宿主
64

3
兔
Compatible Secondaries
克隆类型
55

12
多克隆
标记
20

5

4

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1
This IRF7 antibody is un-conjugated
应用范围
46

18

14

13

12

12

3

3

2

2

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

人, 小鼠, Pig, 大鼠

预测反应

Dog,Cow,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human IRF7

亚型

IgG

Top Product

Discover our top product IRF7 Primary Antibody
anti-Interferon Regulatory Factor 7 (IRF7) (pSer471), (pSer472) antibody
IRF7 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 7 (IRF7) (AA 131-289) antibody
IRF7 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 7 (IRF7) (AA 1-150), (N-Term) antibody
IRF7 适用: 人 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal 3D9 unconjugated

anti-Interferon Regulatory Factor 7 (IRF7) antibody
IRF7 适用: 人 WB, IF (cc) 宿主: 兔 Monoclonal 2A1 unconjugated

anti-Interferon Regulatory Factor 7 (IRF7) (AA 257-516) antibody
IRF7 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 7 (IRF7) (C-Term) antibody
IRF7 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 7 (IRF7) (AA 35-84) antibody
IRF7 适用: 人, 小鼠, 大鼠, 马 WB 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 7 (IRF7) (AA 1-150) antibody
IRF7 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D9 unconjugated

anti-Interferon Regulatory Factor 7 (IRF7) (N-Term) antibody
IRF7 适用: 人, 小鼠, 大鼠, Pig, 斑马鱼, 马, 兔, Cow WB 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 7 (IRF7) (AA 401-503) antibody (Biotin)
IRF7 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal Biotin

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Lopušná, Benkóczka, Lupták, Matúšková, Lukáčiková, Ovečková, Režuchová: "Murine gammaherpesvirus targets type I IFN receptor but not type III IFN receptor early in infection." in: Cytokine, Vol. 83, pp. 158-70, (2016) (PubMed).

Cai, Jiang, Pan, Chen, Zhang, Zhu, Cai, Ling, Chen, Xu, Chen: "Transcriptomic analysis of hepatic responses to testosterone deficiency in miniature pigs fed a high-cholesterol diet." in: BMC genomics, Vol. 16, pp. 59, (2015) (PubMed).

Han, Choi, Uyangaa, Kim, Kim, Kim, Kim, Eo: "Distinct dictation of Japanese encephalitis virus-induced neuroinflammation and lethality via triggering TLR3 and TLR4 signal pathways." in: PLoS pathogens, Vol. 10, Issue 9, pp. e1004319, (2014) (PubMed).
抗原

IRF7 (Interferon Regulatory Factor 7 (IRF7))

别名

IRF7 (IRF7 产品)

别名

wu:fl24c03 antibody, zgc:66043 antibody, zgc:77947 antibody, IRF7 antibody, irf7 antibody, IRF-7H antibody, IRF7A antibody, IRF7B antibody, IRF7C antibody, IRF7H antibody, interferon regulatory factor 7 antibody, irf7 antibody, IRF7 antibody, Irf7 antibody

背景

Synonyms: IRF7A, IRF7B, IRF7C, IRF7H, IRF-7H, Interferon regulatory factor 7, IRF-7, IRF7
Background: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.

基因ID

3665

UniProt

Q92985

途径

TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagy