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MTDH 抗体 (AA 131-230)

Name: MTDH 抗体 (AA 131-230)
SKU: ABIN678863
Availability: OutOfStock

MTDH 适用: 人 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti-AEG-1/LYRIC Polyclonal Antibody, Unconjugated (ABIN678863) at 1:200 followed by conjugation to the secondary antibody and DAB staining. (MTDH 抗体 (AA 131-230))

IHC

1 image

(4 references)

产品编号 ABIN678863

发货至: 中国

Datasheet as PDF

抗原 See all MTDH 抗体

MTDH (Metadherin (MTDH))
抗原表位
15

4

3

2

2

2

2

2

2

1

1

1
AA 131-230
适用
49

18

7

2

1

1

1

1

1
人
宿主
40

7

3
兔
Compatible Secondaries
克隆类型
45

5
多克隆
标记
28

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This MTDH antibody is un-conjugated
应用范围
40

14

12

12

11

9

8

8

7

3

3

2
Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

人

预测反应

Mouse,Rat,Dog,Cow,Pig

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human AEG-1

亚型

IgG

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anti-Metadherin (MTDH) (AA 131-230) antibody (Biotin)
MTDH 适用: 人 WB, ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal Biotin

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Zhang, Li, Qian, Liu, Guo, Lin: "MTDH/AEG-1-based DNA vaccine suppresses metastasis and enhances chemosensitivity to paclitaxel in pelvic lymph node metastasis." in: Biomedicine & pharmacotherapy, Vol. 70, pp. 217-26, (2015) (PubMed).

Guo, Zhang, Liu, Wang, Liu, Wang, Ma, Wu: "Astrocyte elevated gene-1 overexpression in histologically favorable Wilms tumor is related to poor prognosis." in: Journal of pediatric urology, Vol. 10, Issue 2, pp. 317-23, (2014) (PubMed).

Zheng, Li, Wu, Liu, Sun, Yang, Hao, Sheng, Sun, Zhang, Long, Liang, Hu et al.: "Astrocyte elevated gene-1 (AEG-1) shRNA sensitizes Huaier polysaccharide (HP)-induced anti-metastatic potency via inactivating downstream P13K/Akt pathway as well as augmenting cell-mediated immune ..." in: Tumour biology, Vol. 35, Issue 5, pp. 4219-24, (2014) (PubMed).

Guo, Chen, Xi, Chang, Zhang, Zhang: "AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues." in: Journal of biomedical research, Vol. 28, Issue 5, pp. 388-95, (2014) (PubMed).
抗原

MTDH (Metadherin (MTDH))

别名

LYRIC (MTDH 产品)

别名

MGC75963 antibody, 2610103J23Rik antibody, 3D3 antibody, 3D3/Lyric antibody, AEG-1 antibody, AV353288 antibody, D8Bwg1112e antibody, Lyric antibody, AEG1 antibody, LYRIC antibody, LYRIC/3D3 antibody, metadherin antibody, mtdh antibody, MTDH antibody, Mtdh antibody

背景

Synonyms: 3D3, AEG1, AEG-1, LYRIC, LYRIC/3D3, Protein LYRIC, 3D3/LYRIC, Astrocyte elevated gene-1 protein, Lysine-rich CEACAM1 co-isolated protein, Metadherin, Metastasis adhesion protein, MTDH
Background: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

基因ID

92140

UniProt

Q86UE4

途径

Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization