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NRF2 抗体 (pSer40)

Name: NRF2 抗体 (pSer40)
SKU: ABIN676673
Availability: OutOfStock

NFE2L2 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

Formalin-fixed and paraffin embedded rat kidney tissue labeled with Anti-phospho-Nrf2 (Ser40) Polyclonal Antibody (ABIN676673), Unconjugated 1:200 followed by conjugation to the secondary antibody and DAB staining (NRF2 抗体 (pSer40))

IHC

Formalin-fixed and paraffin embedded rat kidney tissue labeled with Anti-phospho-Nrf2 (Ser40) Polyclonal Antibody , Unconjugated 1:200 followed by conjugation to the secondary antibody and DAB staining (NRF2 抗体 (pSer40))

IHC (p)

Formalin-fixed and paraffin embedded rat tongue tissue labeled with Anti-phospho-Nrf2 (Ser40) Polyclonal Antibody (ABIN676673), Unconjugated 1:200 followed by conjugation to the secondary antibody and DAB staining (NRF2 抗体 (pSer40))

SDS

Formalin-fixed and paraffin embedded rat tongue tissue labeled with Anti-phospho-Nrf2 (Ser40) Polyclonal Antibody , Unconjugated 1:200 followed by conjugation to the secondary antibody and DAB staining (NRF2 抗体 (pSer40))

IHC (p)

Formalin-fixed and paraffin embedded human colon carcinoma tissue labeled with Anti-phospho-Nrf2 (Ser40) Polyclonal Antibody (ABIN676673), Unconjugated 1:200 followed by conjugation to the secondary Cy5 antibody and DAPIstaining (NRF2 抗体 (pSer40))

L1 mouse heart, L2 mouse muscle lysates probed (ABIN676673) at 1:200 in 4 °C. (NRF2 抗体 (pSer40))

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-phospho-Nrf2 (Ser40) Polyclonal Antibody, Unconjugated (ABIN676673) at 1:200 followed by conjugation to the secondary antibody and DAB staining (NRF2 抗体 (pSer40))

IHC

7 images

(19 references)

产品编号 ABIN676673

发货至: 中国

Datasheet as PDF

抗原 See all NRF2 (NFE2L2) 抗体

NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))
抗原表位
20

15

9

9

8

8

7

4

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer40
适用
112

54

53

6

4

4

3

3

2

1

1

1

1

1
人, 小鼠, 大鼠, Pig
宿主
104

10

1
兔
Compatible Secondaries
克隆类型
96

19
多克隆
标记
56

10

6

6

4

3

3

3

3

3

3

3

1

1

1

1

1

1

1

1

1

1

1

1
This NRF2 antibody is un-conjugated
应用范围
87

49

24

21

16

15

14

13

12

9

6

2

2

2

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

人, 小鼠, Pig, 大鼠

预测反应

Dog,Cow,Chicken

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic phosphopeptide derived from human Nrf2 around the phosphorylation site of Ser40 [DF(p-S)QR]

亚型

IgG
anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (AA 430-480) antibody
NFE2L2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (AA 366-605) antibody
NFE2L2 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (Internal Region) antibody
NFE2L2 适用: 人, 大鼠 WB, IF, IP, ICC, IHC (p), ChIP 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (AA 382-604) antibody
NFE2L2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (acLys599) antibody
NFE2L2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (N-Term) antibody
NFE2L2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (AA 356-589) antibody
NFE2L2 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 1A6G6 unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (pSer40) antibody
NFE2L2 适用: 人, 小鼠, 大鼠 WB, IHC (p), FACS, IF (cc) 宿主: 兔 Monoclonal 7G4 unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (AA 71-170) antibody
NFE2L2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1B8 unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (AA 71-170) antibody
NFE2L2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2G7 unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Ghosh, Abdo, Zhao, Wu, Shi, Lo, Chenier, Alquier, Filep, Ingelfinger, Zhang, Chan: "Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice." in: Endocrinology, Vol. 158, Issue 4, pp. 903-919, (2017) (PubMed).

Allard, Perez, Fukui, Carpenter, Ingram, de Cabo: "Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice." in: Behavioural brain research, Vol. 301, pp. 1-9, (2016) (PubMed).

Yen, Chen, Jayakumar, Lu, Hsieh, Hsu, Yang, Chang, Lin, Lin, Sheu et al.: "Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection ..." in: Translational research : the journal of laboratory and clinical medicine, Vol. 170, pp. 57-72, (2016) (PubMed).

Ko, Rho, Jeon, Kim, Woo, Kim, Kim: "Crude Preparations of Helicobacter pylori Outer Membrane Vesicles Induce Upregulation of Heme Oxygenase-1 via Activating Akt-Nrf2 and mTOR-IκB Kinase-NF-κB Pathways in Dendritic Cells." in: Infection and immunity, Vol. 84, Issue 8, pp. 2162-74, (2016) (PubMed).

Ko, Rho, Jeon, Kim, Woo, Lee, Kim: "Bacteroides fragilis Enterotoxin Upregulates Heme Oxygenase-1 in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinase- and NF-κB-Dependent Pathway, Leading to Modulation of Apoptosis." in: Infection and immunity, Vol. 84, Issue 9, pp. 2541-54, (2016) (PubMed).

Kim, Kim, Jung, Yang, Park, Jun: "EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage." in: Toxicology and applied pharmacology, Vol. 315, pp. 60-69, (2016) (PubMed).

Cheng, Cheng, Lee, Chung, Chang: "Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo." in: Nutrients, Vol. 7, Issue 4, pp. 2850-65, (2016) (PubMed).

Chang, Wu, Xu, Liao, Wu, Cheng: "Scopoletin Protects against Methylglyoxal-Induced Hyperglycemia and Insulin Resistance Mediated by Suppression of Advanced Glycation Endproducts (AGEs) Generation and Anti-Glycation." in: Molecules (Basel, Switzerland), Vol. 20, Issue 2, pp. 2786-801, (2015) (PubMed).

Kaneko, Takayanagi, Nagasaki, Kodani, Nakashima, Mori, Suzuki, Itoh, Kondo, Nagatsu, Ota, Ota: "Aripiprazole increases NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells." in: Journal of neural transmission (Vienna, Austria : 1996), Vol. 122, Issue 6, pp. 757-72, (2015) (PubMed).

Santofimia-Castaño, Clea Ruy, Garcia-Sanchez, Jimenez-Blasco, Fernandez-Bermejo, Bolaños, Salido, Gonzalez: "Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca(2+) influx activation in mouse pancreatic acinar cells." in: Free radical biology & medicine, (2015) (PubMed).

Mo, Wang, Zhang, Numazawa, Tang, Tang, Han, Li, Yang, Wang, Wei, Xiao: "The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice." in: Antioxidants & redox signaling, Vol. 20, Issue 4, pp. 574-88, (2014) (PubMed).

Kakehashi, Kato, Ishii, Wei, Morimura, Fukushima, Wanibuchi: "Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling." in: PLoS ONE, Vol. 9, Issue 11, pp. e113610, (2014) (PubMed).

Li, Guo, Xi, Yang, Zhou, Yin, Hai, Li, Qin: "Saponins from Aralia taibaiensis attenuate D-galactose-induced aging in rats by activating FOXO3a and Nrf2 pathways." in: Oxidative medicine and cellular longevity, Vol. 2014, pp. 320513, (2014) (PubMed).

Patwardhan, Sharma, Checker, Sandur: "Mitigation of radiation-induced hematopoietic injury via regulation of cellular MAPK/phosphatase levels and increasing hematopoietic stem cells." in: Free radical biology & medicine, Vol. 68, pp. 52-64, (2014) (PubMed).

Lee, Hsu, Hsu, Pan: "Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid." in: Free radical biology & medicine, Vol. 60, pp. 7-16, (2013) (PubMed).

Hsu, Lee, Li, Hsu, Pan: "Monascin and AITC attenuate methylglyoxal-induced PPAR? phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation." in: Journal of agricultural and food chemistry, Vol. 61, Issue 25, pp. 5996-6006, (2013) (PubMed).

Lee, Lee, Cheng, Chang, Hsu, Wu: "Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 62, pp. 492-8, (2013) (PubMed).

Lee, Hsu, Chang, Kuo, Hsu, Pan: "Ankaflavin: a natural novel PPAR? agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo." in: Free radical biology & medicine, Vol. 53, Issue 11, pp. 2008-16, (2012) (PubMed).
抗原

NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

别名

Nrf2 (NFE2L2 产品)

别名

Nrf2 antibody, nfe2l2 antibody, wu:fc15g09 antibody, wu:fj67e03 antibody, NF-E2R2 antibody, NRF2 antibody, AI194320 antibody, nuclear factor, erythroid 2-like 2a antibody, nuclear factor, erythroid 2 like 2 S homeolog antibody, nuclear factor, erythroid 2 like 2 antibody, nuclear factor, erythroid derived 2, like 2 antibody, nuclear factor, erythroid 2-like 2 antibody, nfe2l2a antibody, nfe2l2.S antibody, NFE2L2 antibody, Nfe2l2 antibody

背景

Synonyms: NRF2, Nuclear factor erythroid 2-related factor 2, NF-E2-related factor 2, NFE2-related factor 2, HEBP1, Nuclear factor, erythroid derived 2, like 2, NFE2L2
Background: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

基因ID

4780

UniProt

Q16236

途径

ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling