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ZW10 抗体 (Biotin)

ZW10 适用: 人, 小鼠, 大鼠 ELISA, IHC (fro), IHC (p) 宿主: 兔 Polyclonal Biotin
产品编号 ABIN675610
发货至: 中国
  • 抗原 See all ZW10 抗体
    ZW10 (Zw10 Kinetochore Protein (ZW10))
    适用
    • 43
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    人, 小鼠, 大鼠
    宿主
    • 37
    • 6
    克隆类型
    • 38
    • 5
    多克隆
    标记
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    • 2
    • 1
    • 1
    • 1
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    This ZW10 antibody is conjugated to Biotin
    应用范围
    • 28
    • 17
    • 13
    • 13
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
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    ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    预测反应
    Human,Mouse,Rat
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from mouse ZW10
    亚型
    IgG
    Top Product
    Discover our top product ZW10 Primary Antibody
  • 应用备注
    WB 1:100-1000
    IHC-P 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C for 12 months.
    有效期
    12 months
  • 抗原
    ZW10 (Zw10 Kinetochore Protein (ZW10))
    Abstract
    ZW10 产品
    别名
    HZW10 antibody, KNTC1AP antibody, 6330566F14Rik antibody, MmZw10 antibody, zw10 kinetochore protein antibody, ZW10 antibody, Zw10 antibody
    背景

    Synonyms: Centromere/kinetochore protein zw10, Centromere/kinetochore protein zw10 homolog, HZW 10, HZW10, Kinetochore associated homolog, KNTC1AP, MGC149821, Zeste White 10, Zeste white 10 homolog, ZW 10, ZW 10, centromere/kinetochore protein, ZW 10 kinetochore associated homolog, ZW10 Drosophila homolog centromere/kinetochore protein, ZW10 homolog centromere/kinetochore protein Drosophila, ZW10 homolog centromere/kinetochore protein, ZW10 kinetochore associated homolog, ZW10_MOUSE.

    Background: The mitotic checkpoint ensures that chromosomes are divided equally between daughter cells and is a primary mechanism preventing the chromosome instability often seen in aneuploid human tumors. This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase. It is part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. In mitotic human cells ZW10 resides in a complex with Rod and Zwilch, whereas another ZW10 partner, Zwint-1, is part of a separate complex of structural kinetochore components including Mis12 and Ndc80-Hec1. Zwint-1 is critical for recruiting ZW10 to unattached kinetochores. Depletion from human cells demonstrates that the ZW10 complex is essential for stable binding of a Mad1-Mad2 complex to unattached kinetochores. Thus, ZW10 functions as a linker between the core structural elements of the outer kinetochore and components that catalyze generation of the mitotic checkpoint-derived "stop anaphase" inhibitor.

    基因ID
    9183
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