PDE4D 抗体 (AA 401-550)
-
- 抗原 See all PDE4D 抗体
- PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))
-
抗原表位
- AA 401-550
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This PDE4D antibody is un-conjugated
-
应用范围
- Western Blotting (WB), ELISA, Flow Cytometry (FACS)
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Dog,Cow,Pig,Horse,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human PDE4D
- 亚型
- IgG
- Top Product
- Discover our top product PDE4D Primary Antibody
-
-
- 应用备注
-
WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100 - 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
-
- 抗原
- PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))
- 别名
- PDE4D (PDE4D 产品)
- 背景
-
Synonyms: cAMP specic 3',5' cyclic phosphodiesterase 4D, DKFZp686M11213, FLJ97311, cAMP specic 3' 5' cyclic phosphodiesterase 4D, cAMP specic phosphodiesterase 4D, cAMP specic phosphodiesterase PDE4D, cAMP specic phosphodiesterase PDE4D6, cyclic AMP phosphodiesterase, DPDE 3, DPDE3, Dunce like phosphodiesterase E3, HSPDE4D, PDE 43, PDE43, PDE4DN2, Phosphodiesterase 4D cAMP specic dunce Drosophila homolog phosphodiesterase E3, Phosphodiesterase 4D cAMP specic phosphodiesterase E3 dunce homolog Drosophila, Phosphodiesterase 4D cAMP specic, Phosphodiesterase 4D, cAMP specic dunce, Phosphodiesterase E3 dunce homolog Drosophila, STRK 1, STRK1.
Background: Cyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprise of 5 variants (PDE4D1, D2, D3, D4 and D5). One or more PDE4D subtype variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein protein interactions with cytoskeletal scaffolding proteins.
- 基因ID
- 5144
- 途径
- Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling
-