TEK 抗体 (AA 401-550) (Cy3)
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- 抗原 See all TEK 抗体
- TEK (TEK Tyrosine Kinase, Endothelial (TEK))
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抗原表位
- AA 401-550
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适用
- 人, 小鼠, 大鼠, Cow
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TEK antibody is conjugated to Cy3
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应用范围
- Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- Cow, 人, 小鼠, 大鼠
- 预测反应
- Cow,Pig,Horse
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human Tie2
- 亚型
- IgG
- Top Product
- Discover our top product TEK Primary Antibody
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anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 66-185) antibody
TEK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3A5 unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 571-748) antibodyTEK 适用: 人 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 3F5B9 unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 758-789) antibodyTEK 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 701-800) antibodyTEK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 401-550) antibodyTEK 适用: 人, 小鼠, 大鼠, Cow ELISA, FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 286-465) antibodyTEK 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 701-800) antibodyTEK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5G6 unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (C-Term) antibodyTEK 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 500-750) antibodyTEK 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 758-789), (C-Term) antibodyTEK 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01525-01526 unconjugated
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- 应用备注
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- TEK (TEK Tyrosine Kinase, Endothelial (TEK))
- 别名
- TIE2/CD202b (TEK 产品)
- 别名
- TEK antibody, DKFZp469E064 antibody, AA517024 antibody, Cd202b antibody, Hyk antibody, Tie2 antibody, tie-2 antibody, CD202B antibody, TIE-2 antibody, TIE2 antibody, VMCM antibody, VMCM1 antibody, Tie-2 antibody, tie2 antibody, TEK receptor tyrosine kinase antibody, angiopoietin-1 receptor antibody, TEK tyrosine kinase, endothelial antibody, TEK antibody, LOC100408334 antibody, tek antibody, Tek antibody
- 背景
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Synonyms: TIE2, VMCM, TIE-2, VMCM1, CD22B, Angiopoietin-1 receptor, Endothelial tyrosine kinase, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, hTIE2, p14 TEK, TEK
Background: Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1, SHC1 and TIE1.
- 基因ID
- 7010
- UniProt
- Q02763
- 途径
- RTK signaling, Growth Factor Binding
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