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TEK 抗体 (AA 401-550)

Name: TEK 抗体 (AA 401-550)
SKU: ABIN674649
Availability: OutOfStock

TEK 适用: 人, 小鼠, 大鼠, Cow ELISA, FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

Formalin-fixed and paraffin embedded rat retina tissue labeled with Anti TIE2/CD202b Polyclonal Antibody, Unconjugated (ABIN674649) at 1:200 followed by conjugation to the secondary antibody and DAB staining (TEK 抗体 (AA 401-550))

IHC

1 image

(4 references)

产品编号 ABIN674649

发货至: 中国

Datasheet as PDF

抗原 See all TEK 抗体

TEK (TEK Tyrosine Kinase, Endothelial (TEK))
抗原表位
20

19

15

8

8

7

7

6

4

4

4

4

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 401-550
适用
137

75

52

21

4

3
人, 小鼠, 大鼠, Cow
宿主
129

18

5

3

2
兔
Compatible Secondaries
克隆类型
135

22
多克隆
标记
73

11

8

5

4

3

3

3

3

3

3

3

3

3

3

3

3

3

3

3

3

3

2

1

1

1
This TEK antibody is un-conjugated
应用范围
79

56

39

39

32

29

13

13

11

8

8

6

4

2

2

1
ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

Cow, 人, 小鼠, 大鼠

预测反应

Cow,Pig,Horse

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human Tie2

亚型

IgG

Top Product

Discover our top product TEK Primary Antibody
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 66-185) antibody
TEK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3A5 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 571-748) antibody
TEK 适用: 人 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 3F5B9 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 758-789) antibody
TEK 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 701-800) antibody
TEK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F8 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 286-465) antibody
TEK 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 701-800) antibody
TEK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5G6 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (C-Term) antibody
TEK 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 500-750) antibody
TEK 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 758-789), (C-Term) antibody
TEK 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01525-01526 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 782-815), (C-Term) antibody
TEK 适用: 小鼠 WB 宿主: 兔 Polyclonal RB50277 unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Li, Liu, Liu, Wang, Zhang, Chen, Hui: "Expression of angiopoietins in central nervous system hemangioblastomas is associated with cyst formation." in: Neuroscience letters, Vol. 639, pp. 120-125, (2017) (PubMed).

Xiang, Hu, Shen, Liu, Hua, Zan, Zu, Cui, Ye: "Bone marrow mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke in type 2 diabetic rats." in: Neuroscience letters, Vol. 644, pp. 62-66, (2017) (PubMed).

Tekari, Chan, Sakai, Grad, Gantenbein: "Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells." in: Stem cell research & therapy, Vol. 7, Issue 1, pp. 75, (2016) (PubMed).

Zhao, Hu, Xiang, Gu, Jin, Hua, Zhang, Liu, Zan, Zhang, Zu, Yang, Shi, Zhu, Xu, Cui, Ye: "Intranasal administration of human umbilical cord mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke." in: Brain research, (2015) (PubMed).
抗原

TEK (TEK Tyrosine Kinase, Endothelial (TEK))

别名

TIE2/CD202b (TEK 产品)

别名

TEK antibody, DKFZp469E064 antibody, AA517024 antibody, Cd202b antibody, Hyk antibody, Tie2 antibody, tie-2 antibody, CD202B antibody, TIE-2 antibody, TIE2 antibody, VMCM antibody, VMCM1 antibody, Tie-2 antibody, tie2 antibody, TEK receptor tyrosine kinase antibody, angiopoietin-1 receptor antibody, TEK tyrosine kinase, endothelial antibody, TEK antibody, LOC100408334 antibody, tek antibody, Tek antibody

背景

Synonyms: TIE2, VMCM, TIE-2, VMCM1, CD22B, Angiopoietin-1 receptor, Endothelial tyrosine kinase, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, hTIE2, p14 TEK, TEK
Background: Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1, SHC1 and TIE1.

基因ID

7010

UniProt

Q02763

途径

RTK signaling, Growth Factor Binding