TCF7L2 抗体 (AA 401-550)
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- 抗原 See all TCF7L2 抗体
- TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))
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抗原表位
- AA 401-550
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TCF7L2 antibody is un-conjugated
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应用范围
- ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 大鼠
- 预测反应
- Human,Mouse,Dog,Cow,Pig,Chicken
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human TCF7L2
- 亚型
- IgG
- Top Product
- Discover our top product TCF7L2 Primary Antibody
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- 应用备注
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))
- 别名
- TCF7L2 (TCF7L2 产品)
- 别名
- TCF4B antibody, TCF4E antibody, Tcf-4 antibody, Tcf4 antibody, mTcf-4B antibody, mTcf-4E antibody, tcf4 antibody, XTCF-4 antibody, tcf4e antibody, TCF4 antibody, TCF-4 antibody, TCFL2 antibody, transcription factor 7 like 2 antibody, transcription factor 7-like 2 antibody, transcription factor 7 like 2, T cell specific, HMG box antibody, transcription factor 7 like 2 L homeolog antibody, transcription factor 7-like 2 (T-cell specific, HMG-box) antibody, TCF7L2 antibody, LOC100545943 antibody, Tcf7l2 antibody, tcf7l2 antibody, tcf7l2.L antibody
- 背景
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Synonyms: TCF4, TCF-4, Transcription factor 7-like 2, HMG box transcription factor 4, T-cell-specific transcription factor 4, T-cell factor 4, hTCF-4, TCF7L2
Background: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
- 基因ID
- 6934
- UniProt
- Q9NQB0
- 途径
- WNT signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Regulation of Hormone Metabolic Process, Carbohydrate Homeostasis, Stem Cell Maintenance, Protein targeting to Nucleus
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