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KISS1 抗体 (AA 81-145) (Biotin)

KISS1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (fro), IHC (p) 宿主: 兔 Polyclonal Biotin
产品编号 ABIN672728
发货至: 中国
  • 抗原 See all KISS1 products
    KISS1 (Kisspeptin (KISS1))
    抗原表位
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 81-145
    适用
    人, 小鼠, 大鼠
    宿主
    • 23
    • 1
    克隆类型
    • 23
    • 1
    多克隆
    标记
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KISS1 antibody is conjugated to Biotin
    应用范围
    • 20
    • 13
    • 13
    • 8
    • 2
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    This antibody detects Kisspeptin-10 region of Kisspeptin.
    交叉反应
    人, 小鼠, 大鼠
    预测反应
    Cow,Sheep
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human KISS1
    亚型
    IgG
  • 应用备注
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C for 12 months.
    有效期
    12 months
  • 抗原
    KISS1 (Kisspeptin (KISS1))
    别名
    Kisspeptin (KISS1 产品)
    别名
    metastatin antibody, KiSS-1 metastasis-suppressor antibody, Kiss1 antibody
    背景

    Synonyms: HH13, KiSS-1, Metastasis-suppressor KiSS-1, Kisspeptin-1, KISS1, PP598

    Background: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-1 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-1, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-1 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

    基因ID
    3814
    UniProt
    Q15726
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