TGF beta Receptor 1 (AA 301-400) 抗体 (Biotin)
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- 抗原
- TGF beta Receptor 1
- 抗原表位
- AA 301-400
- 适用
- Cow, 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- Biotin
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应
- Cow, 人, 小鼠, 大鼠
- 预测反应
- Cow
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human TGF-beta R1
- 亚型
- IgG
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anti-TGF beta Receptor 1 (AA 301-400) antibody
适用: Cow, 人, 小鼠, 大鼠 WB, IF (cc), IF (p), ELISA, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TGF beta Receptor 1 (AA 301-400) antibody (FITC)适用: Cow, 人, 小鼠, 大鼠 WB, IF (cc), IF (p) 宿主: 兔 Polyclonal FITC
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- 应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- TGF beta Receptor 1
- 别名
- AAT5 antibody, ACVRLK4 antibody, ALK-5 antibody, ALK5 antibody, LDS1A antibody, LDS2A antibody, MSSE antibody, SKR4 antibody, TGFR-1 antibody, AU017191 antibody, Alk-5 antibody, TbetaR-I antibody, TbetaRI antibody, Alk5 antibody, Skr4 antibody, Tgfr-1 antibody, tbetaR-I antibody, transforming growth factor beta receptor 1 antibody, transforming growth factor, beta receptor I antibody, transforming growth factor, beta receptor 1 antibody, TGFBR1 antibody, Tgfbr1 antibody
- 背景
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Synonyms: AAT5, ALK5, ESS1, LDS1, MSSE, SKR4, ALK-5, LDS1A, LDS2A, TGFR-1, ACVRLK4, TGF-beta receptor type-1, Activin A receptor type II-like protein kinase of 53kD, Activin receptor-like kinase 5, Serine/threonine-protein kinase receptor R4, TGF-beta type I receptor, Transforming growth factor-beta receptor type I, TGF-beta receptor type I, TbetaR-I, TGFBR1
Background: Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 Molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.
- 基因ID
- 7046
- UniProt
- P36897
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