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MMP13 抗体 (AA 201-300)

Name: MMP13 抗体 (AA 201-300)
SKU: ABIN670341
Availability: OutOfStock

MMP13 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

Human U2os lysates probed with Rabbit Anti-MMP13 Polyclonal Antibody, Unconjugated at 1:5000 for 90 min at 37˚C. (MMP13 抗体 (AA 201-300))

Formalin-fixed and paraffin embedded rat articular cartilage labeled with Anti-MMP-13 Polyclonal Antibody (ABIN670341), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining (MMP13 抗体 (AA 201-300))

IHC

Generously provided by Markus Linder from Medical University Vienna as part of the Bioss Discovery Program. (MMP13 抗体 (AA 201-300))

IHC

Formalin-fixed and paraffin embedded human bladder cancer labeled with Rabbit Anti-MMP-13 Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining (MMP13 抗体 (AA 201-300))

IHC (p)

Human PC3 lysates probed with Rabbit Anti-MMP13 Polyclonal Antibody, Unconjugated at 1:5000 for 90 min at 37˚C. (MMP13 抗体 (AA 201-300))

Formalin-fixed and paraffin embedded rat articular cartilage labeled with Anti-MMP-13 Polyclonal Antibody , Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining (MMP13 抗体 (AA 201-300))

IHC (p)

6 images

(7 references)

产品编号 ABIN670341

发货至: 中国

Datasheet as PDF

抗原 See all MMP13 抗体

MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))
抗原表位
15

15

8

8

7

7

6

6

6

6

5

4

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1
AA 201-300
适用
113

50

35

18

10

3

3

2

1

1

1

1

1

1

1
人, 小鼠, 大鼠
宿主
120

13

7
兔
Compatible Secondaries
克隆类型
122

18
多克隆
标记
59

20

13

7

4

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2
This MMP13 antibody is un-conjugated
应用范围
113

59

45

27

26

26

20

16

15

8

8

3

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

人, 小鼠, 大鼠

预测反应

Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human MMP13

亚型

IgG
anti-Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) (AA 103-290) antibody
MMP13 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) antibody
MMP13 适用: 人 WB, IHC, IF, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) (AA 290-468) antibody
MMP13 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) (AA 362-471) antibody
MMP13 适用: 人 WB, ELISA, IP, RNAi 宿主: 小鼠 Monoclonal 3B11 unconjugated

anti-Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) (AA 99-335) antibody
MMP13 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) (AA 70-245) antibody
MMP13 适用: 兔 WB, IHC, IP, ICC 宿主: 豚鼠 Polyclonal unconjugated

anti-Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) (AA 104-471) antibody
MMP13 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) (AA 123-270) antibody
MMP13 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) (N-Term) antibody
MMP13 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) (AA 262-471) antibody
MMP13 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Xiao, Li, Zhang, Xu, Zhang: "Pannexin 3 activates P2X7 receptor to mediate inflammation and cartilage matrix degradation in temporomandibular joint osteoarthritis." in: Cell biology international, Vol. 47, Issue 7, pp. 1183-1197, (2023) (PubMed).

Cao, Bai, Liu, Dou, Li, Xiang, Zhao, Xie, Xiang, Dong: "Hypertrophic differentiation of mesenchymal stem cells is suppressed by xanthotoxin via the p38‑MAPK/HDAC4 pathway." in: Molecular medicine reports, Vol. 16, Issue 3, pp. 2740-2746, (2018) (PubMed).

Yang, Lu, Guo: "Platelet-rich plasma protects rat chondrocytes from interleukin-1β-induced apoptosis." in: Molecular medicine reports, Vol. 14, Issue 5, pp. 4075-4082, (2016) (PubMed).

Ou, Wang, Liu, Li, Yeh, Qi, Chang: "Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals." in: Oncotarget, Vol. 6, Issue 28, pp. 26065-78, (2016) (PubMed).

Ma, Wu, Wang, Wang, Wu, Zhu, Zhao: "Effects of chronic sleep deprivation on the extracellular signal-regulated kinase pathway in the temporomandibular joint of rats." in: PLoS ONE, Vol. 9, Issue 9, pp. e107544, (2014) (PubMed).

Luo, Zhang, Wang, Hu, Song, Su, Zhang: "Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats." in: Bone, Vol. 55, Issue 2, pp. 439-48, (2013) (PubMed).

Zhang, Li, Zhang, Fu, Cui: "Hydrogen sulfide suppresses the expression of MMP-8, MMP-13, and TIMP-1 in left ventricles of rats with cardiac volume overload." in: Acta pharmacologica Sinica, Vol. 34, Issue 10, pp. 1301-9, (2013) (PubMed).
抗原

MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

别名

MMP-13 (MMP13 产品)

别名

CLG3 antibody, MANDP1 antibody, Clg antibody, MMP-13 antibody, Mmp1 antibody, cb1034 antibody, mmp13 antibody, gene A antibody, xCol antibody, xcl3 antibody, MMP13 antibody, MGC108008 antibody, matrix metallopeptidase 13 antibody, matrix metallopeptidase 13a antibody, matrix metallopeptidase 13 (collagenase 3) like S homeolog antibody, matrix metallopeptidase 13 (collagenase 3) antibody, matrix metalloproteinase 13 antibody, matrix metallopeptidase 13 (collagenase 3) like L homeolog antibody, MMP13 antibody, Mmp13 antibody, mmp13a antibody, mmp13l.S antibody, mmp13 antibody, LOC100136348 antibody, mmp13l.L antibody

背景

Synonyms: CLG3, MANDP1, MMP-13, Collagenase 3, Matrix metalloproteinase-13, MMP13
Background: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

基因ID

4322

UniProt

P45452