tau 抗体 (Biotin)
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- 抗原 See all tau 抗体
- tau (tau Protein)
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This tau antibody is conjugated to Biotin
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- Detects ~45.8kda.
- 纯化方法
- Protein A Purified
- 免疫原
- Synthetic peptide from the full length of Human Tau
- Top Product
- Discover our top product tau Primary Antibody
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- 应用备注
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- WB (1:1000)
- optimal dilutions for assays should be determined by the user.
- optimal dilutions for assays should be determined by the user.
- 说明
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A 1:1000 dilution of ABIN6698773 was sufficient for detection of Tau in 10 μg of human SH-SY5Y cell lysate cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4, 50 % glycerol, 0.09 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
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- 抗原
- tau (tau Protein)
- 别名
- Tau (tau 产品)
- 别名
- DDPAC antibody, FTDP-17 antibody, MAPTL antibody, MSTD antibody, MTBT1 antibody, MTBT2 antibody, PPND antibody, TAU antibody, tau antibody, PHF-tau antibody, microtubule associated protein tau antibody, MAPT antibody
- 背景
- Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10 % of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5). P301L (PL) is a mutation where proline is replaced by leucine at codon 301 of tau, and has been linked to frontotemporal dementia (6).
- 基因ID
- 4137
- UniProt
- P10636
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