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Thrombomodulin 抗体

THBD 适用: 人, 大鼠, 小鼠, 犬, Cow WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN669636
发货至: 中国
  • 抗原 See all Thrombomodulin (THBD) 抗体
    Thrombomodulin (THBD)
    适用
    人, 大鼠, 小鼠, 犬, Cow
    宿主
    • 66
    • 52
    • 6
    • 2
    克隆类型
    • 70
    • 55
    • 1
    多克隆
    标记
    • 59
    • 17
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Thrombomodulin antibody is un-conjugated
    应用范围
    • 77
    • 47
    • 43
    • 41
    • 26
    • 22
    • 21
    • 15
    • 13
    • 12
    • 11
    • 11
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    Cow, 犬, 人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from mouse Thrombomodulin
    亚型
    IgG
    Top Product
    Discover our top product THBD Primary Antibody
  • 应用备注
    WB(1:100-500)
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C for 12 months.
    有效期
    12 months
  • 抗原
    Thrombomodulin (THBD)
    别名
    Thrombomodulin (THBD 产品)
    背景

    Synonyms: Thrombomodulin, CD 141, CD141, CD141 antigen, Fetomodulin, THBD, THRM, TM, AHUS 6, AHUS6, BDCA 3, BDCA3, THPH12, TRBM_HUMAN.

    Background: Thrombomodulin, TM is cell surface glycoprotein, plays an important role in the protein C anticoagulant pathway. It located in a vein, artery and capillary endothelial cells on the surface of plasma membrane protein. It is generally believed: TM vascular endothelial injury is an important parameter is the thrombin receptor, known in a variety of normal human tissues, can also be expressed in many tumors, TM may be similar to the E-cadherin,and is a lectin Like activity of a new class of members of the cell adhesion molecules.CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII, thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

    分子量
    61kDa
    基因ID
    21824
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