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CD31 抗体 (AA 601-680)

Name: CD31 抗体 (AA 601-680)
SKU: ABIN669006
Availability: OutOfStock

PECAM1 适用: 人, 小鼠, 大鼠, 兔, Pig, 犬 FACS, WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

Recombinant human CD31 protein probed with CD31 Polyclonal Antibody, unconjugated at 1:300 overnight at 4°C followed by a conjugated secondary antibody at 1:10000 for 90 minutes at 37°C. (CD31 抗体 (AA 601-680))

Formalin-fixed and paraffin embedded rat skin tissue labeled with Anti-CD31/PECAM-1 Polyclonal Antibody, Unconjugated at 1:300, followed by conjugation to the secondary antibody and DAB staining (CD31 抗体 (AA 601-680))

IHC (p)

Human Jurkat cells probed with CD31 Polyclonal Antibody, Unconjugated (green) at 1:100 for 30 minutes followed by a FITC conjugated secondary antibody compared to unstained cells (blue), secondary only (light blue), and isotype control (orange). (CD31 抗体 (AA 601-680))

FACS

Formalin-fixed and paraffin embedded rat skin tissue labeled with Anti-CD31/PECAM-1 Polyclonal Antibody, Unconjugated (ABIN669006) at 1:300, followed by conjugation to the secondary antibody and DAB staining (CD31 抗体 (AA 601-680))

8 images

(15 references)

产品编号 ABIN669006

发货至: 中国

Datasheet as PDF

Key Features
- High quality CD31 Primary Antibody for the detection of PECAM1.
- Reliable product with high standard validation data
抗原 See all CD31 (PECAM1) 抗体

CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))
抗原表位
16

16

15

12

8

8

7

6

5

4

4

4

4

3

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 601-680
适用
262

131

70

58

40

28

20

18

7

4

4

3

2

1

1

1
人, 小鼠, 大鼠, 兔, Pig, 犬
宿主
148

145

41

6

3

2
兔
Compatible Secondaries
克隆类型
214

130

1
多克隆
标记
151

30

29

24

13

5

5

5

5

5

5

5

5

5

5

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1
This CD31 antibody is un-conjugated
应用范围
217

181

97

95

59

36

35

31

25

25

15

15

13

9

6

5

3

2

1

1

1

1

1
Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

交叉反应

犬, 人, 小鼠, Pig, 兔, 大鼠

预测反应

Horse

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from mouse CD31

亚型

IgG

Product Specific Information

What can the CD31 Antibody ABIN669006 be used for?

This polyclonal CD31 Antibody detects CD31. The CD31 Antibody has been validated for various applications and can be used for the detection of CD31 and derivatives by Flow Cytometry, Western Blotting, ELISA, Immunohistochemistry (Paraffin-embedded Sections), Immunohistochemistry (Frozen Sections), Immunofluorescence (Cultured Cells), Immunofluorescence (Paraffin-embedded Sections).

What validation data is available for this CD31 Antibody?

The Primary Antibody is referenced in 15 publications and is characterized by a proven, very high reliability. It has currently 8 product images that show its performance in a variety of applications. CD31 Antibody for the detection of CD31 and derivatives.

What is the function of CD31?

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010].
anti-Platelet/endothelial Cell Adhesion Molecule (PECAM1) (C-Term) antibody
PECAM1 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC (f), IHC (p) 宿主: 山羊 Polyclonal unconjugated

anti-Platelet/endothelial Cell Adhesion Molecule (PECAM1) antibody
PECAM1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Platelet/endothelial Cell Adhesion Molecule (PECAM1) (AA 28-382) antibody
PECAM1 适用: 人, 大鼠 FACS, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Platelet/endothelial Cell Adhesion Molecule (PECAM1) (AA 681-738) antibody
PECAM1 适用: 人, 小鼠, 大鼠, 兔, Pig, Cow FACS, WB, ELISA, IHC (p), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

anti-Platelet/endothelial Cell Adhesion Molecule (PECAM1) (AA 28-315) antibody
PECAM1 适用: 人 FACS, WB, IHC, IF, ELISA 宿主: 小鼠 Monoclonal 9E6E12 unconjugated

anti-Platelet/endothelial Cell Adhesion Molecule (PECAM1) (AA 29-738) antibody
PECAM1 适用: 人 WB, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal 1D2-1A5 unconjugated

anti-Platelet/endothelial Cell Adhesion Molecule (PECAM1) antibody
PECAM1 适用: 人, 兔, Cynomolgus FACS, WB, IHC, IF, StM 宿主: 小鼠 Monoclonal JC-70A unconjugated

anti-Platelet/endothelial Cell Adhesion Molecule (PECAM1) antibody
PECAM1 适用: 人, 大鼠 FACS, WB, IHC, IF, StM 宿主: 小鼠 Monoclonal C31-3 unconjugated

anti-Platelet/endothelial Cell Adhesion Molecule (PECAM1) (AA 625-738) antibody
PECAM1 适用: 人 FACS, IHC, IF, StM 宿主: 小鼠 Monoclonal PECAM1-3527 unconjugated

anti-Platelet/endothelial Cell Adhesion Molecule (PECAM1) antibody
PECAM1 适用: 人, 大鼠, 兔, Cynomolgus FACS, WB, IHC, StM 宿主: 小鼠 Monoclonal C31-7 unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Li, Zhang, Chen, Tian, Wang: "Increased Angiogenic and Adipogenic Differentiation Potentials in Adipose-Derived Stromal Cells from Thigh Subcutaneous Adipose Depots Compared with Cells from the Abdomen." in: Aesthetic surgery journal, Vol. 39, Issue 5, pp. NP140-NP149, (2019) (PubMed).

Vuletic, Zhou, Li, Bai, Meng, Zhu, Ding, Li, Sun, Ren: "Validation of Bevacizumab Therapy Effect on Colon Cancer Subtypes by Using Whole Body Imaging in Mice." in: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, (2017) (PubMed).

Long, Lankford, Kumar, Grahn, Borjesson, Farmer, Wang: "Isolation and characterization of canine placenta-derived mesenchymal stromal cells for the treatment of neurological disorders in dogs." in: Cytometry. Part A : the journal of the International Society for Analytical Cytology, Vol. 93, Issue 1, pp. 82-92, (2017) (PubMed).

Korkmaz, Ulrich, Vogels, de Wit, van Zuijlen, Krijnen, Niessen: "Neutrophil extracellular traps coincide with a pro-coagulant status of microcirculatory endothelium in burn wounds." in: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, Vol. 25, Issue 4, pp. 609-617, (2017) (PubMed).

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Zhou, Yang, Xin, Zhang, Hu, Zhou, Chen, Chen et al.: "Exendin-4 enhances the migration of adipose-derived stem cells to neonatal rat ventricular cardiomyocyte-derived conditioned medium via the phosphoinositide 3-kinase/Akt-stromal cell-derived ..." in: Molecular medicine reports, (2015) (PubMed).

Wang, Wang, Fang, Zhou, Liu, Su: "High glucose induces and activates Toll-like receptor 4 in endothelial cells of diabetic retinopathy." in: Diabetology & metabolic syndrome, Vol. 7, pp. 89, (2015) (PubMed).

Yu, Wang, Wang, Lu, Li, Qin, Huang: "Activation of liver X receptor enhances the proliferation and migration of endothelial progenitor cells and promotes vascular repair through PI3K/Akt/eNOS signaling pathway activation." in: Vascular pharmacology, Vol. 62, Issue 3, pp. 150-61, (2014) (PubMed).

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Zeng, Zhang, Li, Yang, Chen, Liu: "A new method to isolate and culture rat kupffer cells." in: PLoS ONE, Vol. 8, Issue 8, pp. e70832, (2013) (PubMed).

Yuan, Huang, Chu, Li, Li, Si: "A targeted high-efficiency angiogenesis strategy as therapy for myocardial infarction." in: Life sciences, Vol. 90, Issue 17-18, pp. 695-702, (2012) (PubMed).

Yuan, Huang, Chu, Li, Si: "A visible, targeted high-efficiency gene delivery and transfection strategy." in: BMC biotechnology, Vol. 11, pp. 56, (2011) (PubMed).

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Chen, Lin, Kanekura, Su, Lin, Xie, Wu, Li, Chen, Chang: "A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma." in: Cancer research, Vol. 66, Issue 23, pp. 11323-30, (2006) (PubMed).
抗原

CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

别名

CD31 (PECAM1 产品)

别名

CD31 antibody, CD31/EndoCAM antibody, GPIIA' antibody, PECA1 antibody, PECAM-1 antibody, endoCAM antibody, C85791 antibody, Cd31 antibody, Pecam antibody, platelet/endothelial cell adhesion molecule 1 antibody, platelet and endothelial cell adhesion molecule 1 antibody, pecam1 antibody, PECAM1 antibody, Pecam1 antibody

背景

Synonyms: CD31, PECA1, GPIIA', PECAM-1, endoCAM, CD31/EndoCAM, Platelet endothelial cell adhesion molecule, PECAM1
Background: Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-69 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).

基因ID

5175

UniProt

P16284

途径

Regulation of Actin Filament Polymerization