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MMP2 抗体 (AA 31-109)

Name: MMP2 抗体 (AA 31-109)
SKU: ABIN668286
Availability: OutOfStock

MMP2 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

Paraformaldehyde-fixed, paraffin embedded rat brain, Antigen retrieval by boiling in sodium citrate buffer (pH6. (MMP2 抗体 (AA 31-109))

IHC (p)

Formalin-fixed and paraffin embedded rat carotid artery Anti-MMP-2 Polyclonal Antibody , Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining. (MMP2 抗体 (AA 31-109))

IHC (p)

Paraformaldehyde-fixed, paraffin embedded Mouse lung, Antigen retrieval by boiling in sodium citrate buffer (pH6. (MMP2 抗体 (AA 31-109))

IHC (p)

HT1080 lysates probed with MMP-2 Polyclonal Antibody, Unconjugated at 1:300 dilution and 4˚C overnight incubation. (MMP2 抗体 (AA 31-109))

HeLa cells probed with MMP2 Polyclonal Antibody, unconjugated at 1:100 dilution for 30 minutes compared to control cells (blue) and isotype control (orange) (MMP2 抗体 (AA 31-109))

IHC (p)

6 images

(17 references)

产品编号 ABIN668286

发货至: 中国

Datasheet as PDF

抗原 See all MMP2 抗体

MMP2 (Matrix Metalloproteinase 2 (MMP2))
抗原表位
16

16

15

11

11

8

6

6

6

6

5

4

4

4

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
AA 31-109
适用
149

79

65

49

7

5

5

3

2

2

2

1
人, 小鼠, 大鼠, 兔
宿主
123

42
兔
Compatible Secondaries
克隆类型
122

43
多克隆
标记
72

14

13

12

5

3

3

3

3

3

3

3

3

3

3

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This MMP2 antibody is un-conjugated
应用范围
130

54

51

38

38

33

28

25

18

14

12

4

3

3

1

1
Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

人, 小鼠, 兔, 大鼠

预测反应

Cow,Sheep,Pig,Chicken

纯化方法

Purified by Protein A.

免疫原

MAT conjugated synthetic peptide derived from human MMP2

亚型

IgG
anti-Matrix Metalloproteinase 2 (MMP2) (AA 40-280) antibody
MMP2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metalloproteinase 2 (MMP2) antibody
MMP2 适用: 人 WB, IP, IF, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metalloproteinase 2 (MMP2) (AA 401-500) antibody
MMP2 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metalloproteinase 2 (MMP2) (AA 580-660) antibody
MMP2 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metalloproteinase 2 (MMP2) (AA 110-660) antibody
MMP2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metalloproteinase 2 (MMP2) (AA 9-140) antibody
MMP2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 2B11E6 unconjugated

anti-Matrix Metalloproteinase 2 (MMP2) (C-Term) antibody
MMP2 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 豚鼠, 马, 绵羊 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Matrix Metalloproteinase 2 (MMP2) (AA 110-660) antibody
MMP2 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated

anti-Matrix Metalloproteinase 2 (MMP2) (AA 242-396) antibody
MMP2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D1E2 unconjugated

anti-Matrix Metalloproteinase 2 (MMP2) (AA 561-660) antibody
MMP2 适用: 人, 小鼠, 兔 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Zhang, Li, Song, Xiong, Liu, Bai: "Hydroxysafflor yellow A suppresses angiogenesis of hepatocellular carcinoma through inhibition of p38 MAPK phosphorylation." in: Biomedicine & pharmacotherapy, Vol. 109, pp. 806-814, (2019) (PubMed).

Gao, Li, Liu, Wang, Zhang, Li, Bu: "Effect of Telmisartan on Preventing Learning and Memory Deficits Via Peroxisome Proliferator-Activated Receptor-γ in Vascular Dementia Spontaneously Hypertensive Rats." in: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, Vol. 27, Issue 2, pp. 277-285, (2018) (PubMed).

Wang, Chen, Ke, Li: "Ghrelin inhibits atherosclerotic plaque angiogenesis and promotes plaque stability in a rabbit atherosclerotic model." in: Peptides, Vol. 90, pp. 17-26, (2017) (PubMed).

Varghese, Joseph, S R, B S, Sreelekha: "The inhibitory effect of anti- tumor polysaccharide from Punica granatum on metastasis." in: International journal of biological macromolecules, Vol. 103, pp. 1000-1010, (2017) (PubMed).

Vendrov, Stevenson, Alahari, Pan, Wickline, Madamanchi, Runge: "Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice." in: Journal of the American Heart Association, Vol. 6, Issue 11, (2017) (PubMed).

Ni, Ding, Zhou, Qiu, Tang: "Renoprotective effects of berberine through regulation of the MMPs/TIMPs system in streptozocin-induced diabetic nephropathy in rats." in: European journal of pharmacology, Vol. 764, pp. 448-456, (2015) (PubMed).

Madka, Mohammed, Li, Zhang, Kumar, Lightfoot, Wu, Steele, Kopelovich, Rao: "TP53 modulating agent, CP-31398 enhances antitumor effects of ODC inhibitor in mouse model of urinary bladder transitional cell carcinoma." in: American journal of cancer research, Vol. 5, Issue 10, pp. 3030-41, (2015) (PubMed).

Ren, Fan, Mei, Wu, Liu, Pu, You, Liu: "Interferon-γ and celecoxib inhibit lung-tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment." in: Drug design, development and therapy, Vol. 8, pp. 1527-38, (2015) (PubMed).

Zhu, Chen, Chen, Chen, Song, Sun, Zhao: "Activating transcription factor 4 promotes esophageal squamous cell carcinoma invasion and metastasis in mice and is associated with poor prognosis in human patients." in: PLoS ONE, Vol. 9, Issue 7, pp. e103882, (2014) (PubMed).

Zhang, Qi, Cao, Zu, Chen, Li, Qi: "5-Aza-2'-Deoxycytidine Enhances Maspin Expression and Inhibits Proliferation, Migration, and Invasion of the Bladder Cancer T24 Cell Line." in: Cancer biotherapy & radiopharmaceuticals, (2013) (PubMed).

Qin, Fan, Zhao, Cui, Wei, Kohama, Gordon, Li, Gao: "Recombinant human CXCL8(3-72)K11R/G31P regulates smooth muscle cell proliferation and migration through blockage of interleukin-8 receptor." in: IUBMB life, Vol. 65, Issue 1, pp. 67-75, (2013) (PubMed).

Fang, Wu, Huang: "Raloxifene upregulated mesangial cell MMP-2 activity via ER-? through transcriptional regulation." in: Cell biochemistry and biophysics, Vol. 67, Issue 2, pp. 607-13, (2013) (PubMed).

Wu, Ning, Zeng, Fan, Zhou, Zhang, Zhang, Chen, Gao, Wang, Guo, Li, Wang, He: "Silibinin inhibits ?-catenin/ZEB1 signaling and suppresses bladder cancer metastasis via dual-blocking epithelial-mesenchymal transition and stemness." in: Cellular signalling, Vol. 25, Issue 12, pp. 2625-33, (2013) (PubMed).

Wu, Fan, Zhang, Ning, Zeng, Zhou, Li, Chen, Zhang, Wang, Hsieh, He: "PI3K/Akt to GSK3?/?-catenin signaling cascade coordinates cell colonization for bladder cancer bone metastasis through regulating ZEB1 transcription." in: Cellular signalling, Vol. 24, Issue 12, pp. 2273-82, (2012) (PubMed).

Wu, Zeng, Zhou, Fan, Chen, Wang, Zhang, Wang, He: "Slug contributes to cadherin switch and malignant progression in muscle-invasive bladder cancer development." in: Urologic oncology, (2012) (PubMed).

Wu, Zeng, Li, Fan, Zhang, Xue, Zhu, Yang, Wang, He: "Silibinin reverses epithelial-to-mesenchymal transition in metastatic prostate cancer cells by targeting transcription factors." in: Oncology reports, Vol. 23, Issue 6, pp. 1545-52, (2010) (PubMed).
抗原

MMP2 (Matrix Metalloproteinase 2 (MMP2))

别名

MMP2 (MMP2 产品)

别名

2-MMP antibody, CG1794 antibody, DM2-MMP antibody, Dm2-MMP antibody, Dmel\\CG1794 antibody, MMP2 antibody, anon-WO0118547.84 antibody, dm-2MMP antibody, dmmp2 antibody, l(2)02353 antibody, mmp2 antibody, wu:fa99h12 antibody, wu:fk89d01 antibody, fgmmp-2 antibody, Mmp-2 antibody, LOC100135793 antibody, Clg4a antibody, GelA antibody, MMP-2 antibody, CLG4 antibody, CLG4A antibody, MMP-II antibody, MONA antibody, TBE-1 antibody, matrix metallopeptidase 2 antibody, Matrix metalloproteinase 2 antibody, matrix metalloproteinase 2 antibody, matrix metalloproteinase-2 antibody, MMP2 antibody, Mmp2 antibody, mmp2 antibody, LOC657982 antibody, LOC100135793 antibody

背景

Synonyms: CLG4, MONA, CLG4A, MMP-2, TBE-1, MMP-II, 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP2
Background: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

基因ID

4313

UniProt

P08253

途径

Activation of Innate immune Response