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- 抗原 See all GRM1a / GRM5 (GRM5/1a) products
- GRM1a / GRM5 (GRM5/1a) (Glutamate Receptor, Metabotropic 5/1a (GRM5/1a))
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抗原表位
- C-Term
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GRM1a / GRM5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 交叉反应
- 小鼠, 大鼠
- 交叉反应 （详细）
- Cross reactivity with mGluR5/1a from other species has not been determined.
- 纯化方法
- Anti-mGluR5/1a antibody is directed against GluR5/1a. GluR5/1a antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling is blocked by preadsorption of antibody with the peptide used as antigen to generate the antibody. The antibody is a total IgG fraction. Expect reactivity with the following species based on sequence homology: human, mouse, rat.
- 免疫原
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Immunogen: Anti-mGluR5/1a Antibody was produced in rabbit by repeated immunizations with synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.
Immunogen Type: Peptide
- 亚型
- IgG
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anti-Glutamate Receptor, Metabotropic 5/1a (GRM5/1a) (C-Term) antibody
GRM5/1a 适用: 大鼠, 人, 小鼠 WB, IHC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 5/1a (GRM5/1a) (C-Term) antibodyGRM5/1a 适用: 大鼠, 人, 小鼠 WB, IHC (fro) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Immunohistochemistry Dilution: 1:500
Application Note: Anti-mGluR5/1a (Rabbit) antibody is suitable for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 125 kDa monomer and 250 kDa dimer in size corresponding to mGluR5 and mGluR1 proteins in the appropriate cell lysate or extract.
Western Blot Dilution: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
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- 抗原
- GRM1a / GRM5 (GRM5/1a) (Glutamate Receptor, Metabotropic 5/1a (GRM5/1a))
- 别名
- mGluR5/1a (GRM5/1a 产品)
- 别名
- mGluR5 antibody, mGlur5 antibody, glutamate metabotropic receptor 5 antibody, Grm5 antibody
- 背景
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Synonyms: mGluR5, Metabotropic Glutamate Receptor 5/1a
Background: mGluR5/1a antibody detects GluR5/1a protein. The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse. Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity. In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus. mGluR5/1a is ideal for investigators involved neuronal circuitry and more generally in Neuroscience.
Gene Name: GRM5
- 基因ID
- 24418
- UniProt
- P31424
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