IP3 Receptor 抗体 (C-Term)
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- 抗原 See all IP3 Receptor (ITP-R83A) 抗体
- IP3 Receptor (ITP-R83A) (Inositol 1,4,5,-Tris-Phosphate Receptor (ITP-R83A))
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抗原表位
- C-Term
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适用
- 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This IP3 Receptor antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Anti-IP3 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with IP3 from Human, Mouse, and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with IP3 from other sources has not been determined. Ion Channels research.
- 免疫原
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Immunogen: IP3 Receptor Antibody was produced in mice by repeated immunizations raised against a fusion protein of the cytoplasmic carboxyl terminus region of rat type1 IP3R inositol 1,4,5-triphosphate receptor type 1, Itpr1.
Immunogen Type: Recombinant Protein
- 克隆位点
- S24-18
- 亚型
- IgG1
- Top Product
- Discover our top product ITP-R83A Primary Antibody
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anti-Inositol 1,4,5,-Tris-Phosphate Receptor (ITP-R83A) antibody
ITP-R83A 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Immunohistochemistry Dilution: 0.1-1.0 μg/mL
Application Note: Anti-IP3 Antibody is suitable for use in WB, IP, and IHC. Expect a band approximately ~300 kDa on specific lysates. Does not recognize type 2 or type 3 IP3R's. Specific conditions for reactivity should be optimized by the end user.
Western Blot Dilution: 1 μg/mL
IF Microscopy Dilution: 1.0-10 μg/mL
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 50 % (v/v) Glycerol
0.09 % (w/v) Sodium Azide - 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- RT,4 °C,-20 °C
- 储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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- 抗原
- IP3 Receptor (ITP-R83A) (Inositol 1,4,5,-Tris-Phosphate Receptor (ITP-R83A))
- 别名
- IP3 Receptor (ITP-R83A 产品)
- 背景
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Synonyms: IP3 Receptor, S24-18,Inositol 1,4,5-trisphosphate receptor type 1,IP3 receptor isoform 1, IP-3-R, IP3R1,Type 1 inositol 1,4,5-trisphosphate receptor, Insp3r
Background: Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family, and is located in the endoplasmic reticulum. It functions as a Ca2+ release channel for intracellular stores of calcium ions. There are three types of IP3 receptors (IP3 receptor 1, 2 and 3) that require the second messenger inositol 1,4,5-triphosphate (IP3) for activation. Four individual receptor subunits, resulting in homo- or heterooligomerization of the receptor isoform, form a functional channel. Phosphorylation of IP3R1 at Ser1756 by cyclic- AMP-dependent protein kinase A (PKA) regulates the sensitivity of IP3R1 to IP3 and may thus be a mode of regulation for Ca2+ release. IP3R1 mediated calcium release appears to have an effect on the induction of long term depression (LTD) in Purkinje cells.
Gene Name: Itpr1
- 基因ID
- 25262
- NCBI登录号
- NP_001007236
- UniProt
- P29994
- 途径
- Fc-epsilon Receptor Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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