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ITPR1 抗体 (C-Term)

ITPR1 适用: 大鼠 IHC, WB, FM 宿主: 小鼠 Monoclonal S24-18 unconjugated
产品编号 ABIN6658135
发货至: 中国
  • 抗原 See all ITPR1 抗体
    ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))
    抗原表位
    • 12
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 54
    • 33
    • 31
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    大鼠
    宿主
    • 51
    • 2
    小鼠
    克隆类型
    • 50
    • 4
    单克隆
    标记
    • 36
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This ITPR1 antibody is un-conjugated
    应用范围
    • 22
    • 20
    • 18
    • 12
    • 8
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), Fluorescence Microscopy (FM)
    原理
    IP3 Receptor Antibody
    交叉反应 (详细)
    A BLAST analysis was used to suggest cross-reactivity with IP3 from Human, Mouse, and Rat based on 100 % homology with the immunizing sequence.
    纯化方法
    Anti-IP3 Antibody was purified by Protein G chromatography.
    过滤
    Sterile filtered
    免疫原
    IP3 Receptor Antibody was produced in mice by repeated immunizations raised against a fusion protein of the cytoplasmic carboxyl terminus region of rat type1 IP3R inositol 1,4,5-triphosphate receptor type 1, Itpr1.
    克隆位点
    S24-18
    亚型
    IgG1
    Top Product
    Discover our top product ITPR1 Primary Antibody
  • 应用备注

    Immunohistochemistry_Dilution: 0.1-1.0 μg/mL

    IF_Microscopy_Dilution: 1.0-10 μg/mL

    Western_Blot_Dilution: 1 μg/mL

    说明

    Anti-IP3 Antibody is tested for use in WB, IP, and IHC. Expect a band approximately ~300kDa on specific lysates. Does not recognize type 2 or type 3 IP3R's. Specific conditions for reactivity should be optimized by the end user.

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: 50 % (v/v) Glycerol

    Preservative: 0.09 % (w/v) Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
    有效期
    12 months
  • 抗原
    ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))
    别名
    Itpr1 (ITPR1 产品)
    别名
    D6Pas2 antibody, ENSMUSG00000072853 antibody, Gm10429 antibody, IP3R1 antibody, InsP3R antibody, Ip3r antibody, Itpr-1 antibody, P400 antibody, Pcp-1 antibody, Pcp1 antibody, opt antibody, I145TR antibody, InsP3R1 antibody, INSP3R1 antibody, IP3R antibody, SCA15 antibody, SCA16 antibody, SCA29 antibody, inositol 1,4,5-trisphosphate receptor type 1 antibody, inositol 1,4,5-trisphosphate receptor 1 antibody, inositol 1,4,5-trisphosphate receptor, type 1 antibody, ITPR1 antibody, Itpr1 antibody
    背景

    Synonyms: IP3 Receptor, S24-18,Inositol 1,4,5-trisphosphate receptor type 1,IP3 receptor isoform 1, IP-3-R, IP3R1,Type 1 inositol 1,4,5-trisphosphate receptor, Insp3r

    Background: Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family, and is located in the endoplasmic reticulum. It functions as a Ca2+ release channel for intracellular stores of calcium ions. There are three types of IP3 receptors (IP3 receptor 1, 2 and 3) that require the second messenger inositol 1,4,5-triphosphate (IP3) for activation. Four individual receptor subunits, resulting in homo- or heterooligomerization of the receptor isoform, form a functional channel. Phosphorylation of IP3R1 at Ser1756 by cyclic- AMP-dependent protein kinase A (PKA) regulates the sensitivity of IP3R1 to IP3 and may thus be a mode of regulation for Ca2+ release. IP3R1 mediated calcium release appears to have an effect on the induction of long term depression (LTD) in Purkinje cells.

    Gene Name: Itpr1

    基因ID
    25262
    NCBI登录号
    NP_001007236
    UniProt
    P29994
    途径
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, Synaptic Membrane, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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