NOXA 抗体
(1 reference)-
- 抗原 See all NOXA (PMAIP1) 抗体
- NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This NOXA antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 交叉反应
- 人, 小鼠
- 纯化方法
- Anti-Noxa Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-Noxa from human and mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-Noxa from other sources has not been determined.
- 免疫原
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Immunogen: Noxa Antibody was produced in mice prepared by repeated immunizations with the human protein Noxa.
Immunogen Type: Recombinant Protein
- 克隆位点
- 114C307-1
- 亚型
- IgG1
- Top Product
- Discover our top product PMAIP1 Primary Antibody
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anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) (AA 1-54) antibody
PMAIP1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) (AA 1-54) antibodyPMAIP1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1A2D3 unconjugated
anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) (AA 1-136) antibodyPMAIP1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) (AA 1-136) antibodyPMAIP1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) (Internal Region) antibodyVerified PMAIP1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) (N-Term) antibodyPMAIP1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Immunohistochemistry Dilution: 5 μg/mL
Application Note: Anti-Noxa antibody is suitable for use by IF/ICC, IHC (p) and WB. Expect a band approximately 6 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.
Western Blot Dilution: 1-2 μg/mL
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.20.02 % (w/v) Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- RT,4 °C,-20 °C
- 储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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: "Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in mice." in: Cell death & disease, Vol. 8, Issue 1, pp. e2556, (2017) (PubMed).
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: "Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in mice." in: Cell death & disease, Vol. 8, Issue 1, pp. e2556, (2017) (PubMed).
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- 抗原
- NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))
- 别名
- Noxa (PMAIP1 产品)
- 别名
- TN3 antibody, PMAIP1 antibody, zgc:162379 antibody, APR antibody, NOXA antibody, Noxa antibody, phorbol-12-myristate-13-acetate-induced protein 1 antibody, PMAIP1 antibody, pmaip1 antibody, Pmaip1 antibody
- 背景
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Synonyms: NOXA, Phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1, Immediate-early-response protein APR, Protein Noxa
Background: Anti-Noxa antibody detects human Noxa. Recently, a BH-3 only member of the Bcl-2 family have been identified in human and mouse and designated as Noxa (for damage). The expression of the Noxa gene involves direct activation of its promoter by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Noxa cDNA codes for a 103-amino acid protein. The coimmunoprecipitation data suggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as, Bcl-XL and Mcl-1. Oda et al. have also shown that blocking the endogenous Noxa induction results in the suppression of apoptosis. Treatment of cells with Noxa antisense oligonucleotides blocks radiation-induced apoptosis suggesting that Noxa may represent a mediator of p53-dependent apoptosis. Anti-Noxa antibody is ideal for investigators involved in apaoptosis research.
Gene Name: PMAIP1
- 基因ID
- 5366
- NCBI登录号
- NP_066950
- UniProt
- Q13794
- 途径
- p53 Pathway, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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