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- 抗原 See all GRK2 (ADRBK1) 抗体
- GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 山羊
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克隆类型
- 多克隆
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标记
- This GRK2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人, 小鼠
- 纯化方法
- This affinity purified antibody is directed against human GRK2. This product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis of the sequence shows 100% reactivity to human, and 90% to rat, mouse, and golden hamster.
- 免疫原
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Immunogen: Anti-GRK2 antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to a near C-terminal portion of human GRK2 conjugated to Keyhole Limpet Hemocyanin (KLH).
Immunogen Type: Peptide
- 亚型
- IgG
- Top Product
- Discover our top product ADRBK1 Primary Antibody
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anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (AA 440-689) antibody
ADRBK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (C-Term) antibodyKO Validated ADRBK1 适用: 人 WB, IHC (p), IF, ICC, FACS, IP 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) antibodyADRBK1 适用: 人 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (Internal Region) antibodyADRBK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (AA 633-660), (C-Term) antibodyADRBK1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0982 unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (C-Term) antibodyADRBK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (N-Term) antibodyADRBK1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (AA 2-221) antibodyADRBK1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (Ser129) antibodyADRBK1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (C-Term) antibodyADRBK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Immunohistochemistry Dilution: 1:1000
Application Note: Anti-GRK2 Antibody has been tested in ELISA, Western Blot, and IHC. Expect a band at ~79.6 kDa in western blot using appropriate lysates. Positive control used: Human high grade lymphoma tissue in Immunohistochemistry and THP-1 lysate in western blot.
ELISA Dilution: 1:10,000-1:50,000
Western Blot Dilution: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.01 % (w/v) Sodium Azide - 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- RT,4 °C,-20 °C
- 储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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- 抗原
- GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
- 别名
- GRK2 (ADRBK1 产品)
- 别名
- Adrbk-1 antibody, Bark-1 antibody, GRK2 antibody, betaARK1 antibody, BARK1 antibody, BETA-ARK1 antibody, GRK-2 antibody, Grk2 antibody, beta-adrenergic receptor kinase 1 antibody, G protein-coupled receptor kinase 2 antibody, Tsp_00497 antibody, grk2 antibody, Grk2 antibody, GRK2 antibody
- 背景
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Synonyms: Goat Anti-G Protein-Coupled Receptor Kinase 2 Antibody, Goat Anti-GRK2 Antibody, Beta-ARK-1, ADRBK1, BARK1, G-Protein Coupled Receptor Kinase 2, Adrenergic, Beta, Receptor Kinase 1, Adrenergic Beta Receptor Kinase 1, Beta-Adrenergic Receptor Kinase 1, EC 2.7.11.15, BETA-ARK1, BARK
Background: GRK2 (G Protein-Coupled Receptor Kinase 2) is a member of the G protein-coupled receptor kinase family of proteins. GRK2 Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. It is a key regulator of LPAR1 signaling. GRK2 competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. It desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. And positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. Anti-GRK2 Antibody is useful for researchers interested in Neuroscience, Cytokines & Growth Factors, and Stem Cell Research.
Gene Name: GRK2
- 基因ID
- 156
- NCBI登录号
- NP_001610
- UniProt
- P25098
- 途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling
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