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GRK2 抗体 (C-Term)

Name: GRK2 抗体 (C-Term)
SKU: ABIN6655844
Availability: OutOfStock

Rockland 600-101-mh5 ADRBK1 适用: 人 WB, ELISA, IHC, FM 宿主: 山羊 Polyclonal unconjugated

Western Blot of Gt Anti-GRK2 Antibody - Western Blot of Goat Anti-GRK2 Antibody. (GRK2 抗体 (C-Term))

Immunohistochemistry of Goat Anti-GRK2 Antibody Immunohistochemistry of Goat Anti-GRK2 Antibody. (GRK2 抗体 (C-Term))

IHC

Western Blot of Goat Anti-GRK2 Antibody Western Blot of Goat Anti-GRK2 Antibody. (GRK2 抗体 (C-Term))

3 images

产品编号 ABIN6655844

Supplier Product No.: 600-101-mh5

发货至: 中国

Datasheet as PDF

抗原 See all GRK2 (ADRBK1) 抗体

GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
抗原表位
16

10

10

6

6

5

4

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
C-Term
适用
89

67

46

9

6

5

4

4

4

2

2

1
人
宿主
84

8

2

1
山羊
Compatible Secondaries
克隆类型
79

16
多克隆
标记
56

6

6

4

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This GRK2 antibody is un-conjugated
应用范围
53

40

32

18

14

13

5

5

3

2

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Fluorescence Microscopy (FM)

Supplier Product No.

600-101-mh5

Supplier

Rockland

原理

GRK2 Antibody

交叉反应（详细）

This affinity purified antibody is directed against human GRK2.

纯化方法

This product was affinity purified from monospecific antiserum by immunoaffinity purification.

过滤

Sterile filtered

免疫原

Anti-GRK2 antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to a near C-terminal portion of human GRK2 conjugated to Keyhole Limpet Hemocyanin (KLH).

亚型

IgG

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anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (C-Term) antibody
ADRBK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

ELISA_Dilution: 1:10,000-1:50,000
Immunohistochemistry_Dilution: 1:1000
IF_Microscopy_Dilution: 15 μg/mL
Western_Blot_Dilution: 1:1000

说明

Anti-GRK2 Antibody has been tested in Western Blot and IHC. Expect a band at ~79.6kDa in western blot using appropriate lysates. Positive control used: Human high grade lymphoma tissue in Immunohistochemistry and THP-1 lysate in western blot.

限制

仅限研究用
状态

Liquid

缓冲液

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

有效期

12 months
抗原

GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

别名

GRK2 (ADRBK1 产品)

背景

Synonyms: Goat Anti-G Protein-Coupled Receptor Kinase 2 Antibody, Goat Anti-GRK2 Antibody, Beta-ARK-1, ADRBK1, BARK1, G-Protein Coupled Receptor Kinase 2, Adrenergic, Beta, Receptor Kinase 1, Adrenergic Beta Receptor Kinase 1, Beta-Adrenergic Receptor Kinase 1, EC 2.7.11.15, BETA-ARK1, BARK
Background: GRK2 (G Protein-Coupled Receptor Kinase 2) is a member of the G protein-coupled receptor kinase family of proteins. GRK2 Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. It is a key regulator of LPAR1 signaling. GRK2 competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. It desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. And positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. Anti-GRK2 Antibody is useful for researchers interested in Neuroscience, Cytokines & Growth Factors, and Stem Cell Research.
Gene Name: GRK2

基因ID

156

NCBI登录号

NP_001610

UniProt

P25098

途径

EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling