Bax Inhibitor 1 抗体 (C-Term, N-Term)
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- 抗原 See all Bax Inhibitor 1 (TMBIM6) 抗体
- Bax Inhibitor 1 (TMBIM6) (Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6))
- 抗原表位
- C-Term, N-Term
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Bax Inhibitor 1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 纯化方法
- Anti-Bi-1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-Bi-1 from human, mouse and rat based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-Bi-1 from other sources has not been determined.
- 免疫原
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Immunogen: Bi-1 Antibody was produced in mice prepared by repeated immunizations of a mixture of three synthetic peptides corresponding to the N-terminus, internal and C-terminus of human Bi-1 protein.
Immunogen Type: Peptide
- 克隆位点
- 20F430
- 亚型
- IgG2b
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anti-Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6) antibody
TMBIM6 适用: 人 WB 宿主: 小鼠 Monoclonal 20F248 unconjugated
anti-Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6) antibodyTMBIM6 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 20F565 unconjugated
anti-Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6) (AA 1-200) antibodyTMBIM6 适用: 人 WB 宿主: 小鼠 Monoclonal ABM20E4 unconjugated
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- 应用备注
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Immunohistochemistry Dilution: 5-10 μg/mL
Application Note: Anti-Bi-1 antibody is suitable for use in IHC (p). Specific conditions for reactivity should be optimized by the end user.
Western Blot Dilution: 1:500-1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 0.2 % Gelatin
0.05 % (w/v) Sodium Azide - 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- RT,4 °C,-20 °C
- 储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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- 抗原
- Bax Inhibitor 1 (TMBIM6) (Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6))
- 别名
- Bi-1 (TMBIM6 产品)
- 别名
- ARABIDOPSIS BAX INHIBITOR 1 antibody, ATBI-1 antibody, ATBI1 antibody, BAX INHIBITOR 1 antibody, BAX inhibitor 1 antibody, BI-1 antibody, K14A3.7 antibody, K14A3_7 antibody, BAXI1 antibody, TEGT antibody, 5031406P05Rik antibody, Bi1 antibody, Tegt antibody, Ab1-011 antibody, Ac1-149 antibody, Cc1-27 antibody, BAX inhibitor 1 antibody, transmembrane BAX inhibitor motif containing 6 antibody, BI1 antibody, TMBIM6 antibody, Tmbim6 antibody
- 背景
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Synonyms: BI1, TEGT, Bax inhibitor 1, BI-1, Testis-enhanced gene transcript protein,Transmembrane BAX inhibitor motif-containing protein 6
Background: Anti-Bi-1 antibody detects human Bi-1. BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007). BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli. Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress-causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury. Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, it is thought to involve regulation of Ca2+ handling by the ER. Anti-Bi-1 antibody is ideal for investigators involved in apoptosis research.
Gene Name: TMBIM6
- 基因ID
- 7009
- NCBI登录号
- NP_001092046
- UniProt
- P55061
- 途径
- Response to Water Deprivation, ER-Nucleus Signaling
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