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Progesterone Receptor 抗体 (AA 412-526)

Name: Progesterone Receptor 抗体 (AA 412-526)
SKU: ABIN6655214
Availability: OutOfStock

Rockland 900-c01-b36 PGR 适用: 人 WB, IHC, ELISA 宿主: 兔 Monoclonal SP2 unconjugated

Anti Progesterone Receptor (PR) monoclonal antibody - Immunohistochemistry. (Progesterone Receptor 抗体 (AA 412-526))

IHC

Anti Progesterone Receptor monoclonal antibody - Immunohistochemistry. (Progesterone Receptor 抗体 (AA 412-526))

IHC

2 images

(2 references)

产品编号 ABIN6655214

Supplier Product No.: 900-c01-b36

发货至: 中国

Datasheet as PDF

抗原 See all Progesterone Receptor (PGR) 抗体

Progesterone Receptor (PGR)
抗原表位
16

16

15

11

10

10

9

8

8

8

6

5

5

4

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 412-526
适用
206

40

37

16

15

8

6

6

5

3

3

2

1

1

1

1

1
人
宿主
145

65

1
兔
Compatible Secondaries
克隆类型
140

70

1
单克隆
标记
125

15

10

9

6

5

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1
This Progesterone Receptor antibody is un-conjugated
应用范围
171

82

56

33

29

26

26

23

18

18

17

11

6

3

2

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Supplier Product No.

900-c01-b36

Supplier

Rockland

原理

Progesterone Receptor Antibody

交叉反应（详细）

The antibody is specific for human Progesterone Receptor protein.

纯化方法

This product is clarified tissue culture supernate.

过滤

Sterile filtered

免疫原

Anti-Progesterone Receptor monoclonal antibody was produced by repeated immunizations with a recombinant protein corresponding to amino acid residues 412-526 of human Progesterone Receptor protein. The hybridoma was produced by fusing New Zealand White rabbit splenocytes and myeloma cells using conventional technology.

克隆位点

SP2

亚型

IgG

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anti-Progesterone Receptor (PGR) (pSer400) antibody
PGR 适用: 人, 猴 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

ELISA_Dilution: 1:10,000
Immunohistochemistry_Dilution: 1:400
Western_Blot_Dilution: 1:200-1:500

说明

This monoclonal antibody contains TBS/1% BSA. Anti-Progesterone Receptor has been tested in IHC and is suitable for ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 116 kDa in size corresponding to PgR isoform B (the 'canonical' sequence) protein by western blotting in the appropriate cell lysate or extract. Progesterone Receptor is found in human Breast ductal carcinoma and is a nuclear protein. For immunohistochemistry, samples should be formalin fixed and paraffin embedded. Deparaffinize slides using xylene or xylene alternatives and graded alcohols. Staining requires boiling of sections in 10 mM citrate buffer pH 6.0 for 10 min followed by cooling at RT for 20 min.

限制

仅限研究用
状态

Liquid

缓冲液

Buffer: See application note.
Stabilizer: 10 mg/mL Bovine Serum Albumin (BSA) - Immunoglobulin and Protease free
Preservative: 0.1 % (w/v) Sodium Azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Store at 2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.

有效期

6 months
Huang, Zhu, Szekeres, Xia: "Development of new rabbit monoclonal antibody to estrogen receptor: immunohistochemical assessment on formalin-fixed, paraffin-embedded tissue sections." in: Applied immunohistochemistry & molecular morphology : AIMM, Vol. 13, Issue 1, pp. 91-5, (2005) (PubMed).

Cano, Milanezi, Leitão, Ricardo, Brito, Schmitt: "Estimation of hormone receptor status in fine-needle aspirates and paraffin-embedded sections from breast cancer using the novel rabbit monoclonal antibodies SP1 and SP2." in: Diagnostic cytopathology, Vol. 29, Issue 4, pp. 207-11, (2004) (PubMed).
抗原

Progesterone Receptor (PGR)

别名

Progesterone Receptor (PGR 产品)

背景

Synonyms: rabbit anti-Progesterone Receptor Antibody, PgR, PR, nuclear receptor subfamily 3 group C member 3
Background: The PGR gene encodes a member of the steroid receptor superfamily referred to as progesterone receptor (also known as PgR, PR and nuclear receptor subfamily 3 group C member 3). Progesterone receptor mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform A only, and mediate their own response genes and physiologic effects with little overlap. Ideal for Cancer, Chromatin & Nuclear Signaling and Signal Transduction research.
Gene Name: PGR

基因ID

5241

UniProt

P06401

途径

Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration