CD44v3 抗体
适用: 人
IHC (p)
宿主: 小鼠
Monoclonal
3G5
unconjugated
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- 抗原
- CD44v3
- 适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
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标记
- 非结合性
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- Purified
- 纯度
- Protein G affinity chromatography
- 免疫原
- An amino acid sequence from the variant 3 domain of CD44 was used as the immunogen for the CD44v3 antibody.
- 克隆位点
- 3G5
- 亚型
- IgG1 kappa
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- 应用备注
- Titering of the CD44v3 antibody may be required for optimal performance.\. Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT
- 限制
- 仅限研究用
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- 缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store the CD44v3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- 抗原
- CD44v3
- 背景
- This antibody recognizes an epitope encoded by exon v3 on the variant portion of human CD44. The CD44 Molecule belongs to a family of cellular adhesion molecules found on a wide range of normal and malignant cells in epithelial, mesothelial and hemopoiesis tissues. It is a single gene with 20 exons, of which 10 are normally expressed to encode the basic CD44 (H-CAM) molecule. The additional 10 exons (v1 to v10) are only expressed by alternative splicing of the nuclear RNA. The expression of specific cell adhesion molecule CD44 splice variants has been reported to be associated with metastasis in certain human malignancies.
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