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- 抗原 See all SFPQ 抗体
- SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))
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抗原表位
- AA 676-705, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SFPQ antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 预测反应
- M
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This SFPQ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 676-705 amino acids from the C-terminal region of human SFPQ.
- 克隆位点
- RB34049
- 亚型
- Ig Fraction
- Top Product
- Discover our top product SFPQ Primary Antibody
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anti-Splicing Factor Proline/glutamine-Ric (SFPQ) (AA 269-361) antibody
SFPQ 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 6D7 unconjugated
anti-Splicing Factor Proline/glutamine-Ric (SFPQ) (AA 578-707) antibodySFPQ 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Splicing Factor Proline/glutamine-Ric (SFPQ) antibodySFPQ 适用: 人 IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Splicing Factor Proline/glutamine-Ric (SFPQ) antibodySFPQ 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Splicing Factor Proline/glutamine-Ric (SFPQ) (N-Term) antibodySFPQ 适用: 人, 小鼠, 大鼠, Cow, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Splicing Factor Proline/glutamine-Ric (SFPQ) (C-Term) antibodySFPQ 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Splicing Factor Proline/glutamine-Ric (SFPQ) (AA 191-240) antibodySFPQ 适用: 人, 小鼠, 大鼠, Cow, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Splicing Factor Proline/glutamine-Ric (SFPQ) (AA 444-493) antibodySFPQ 适用: 人, 小鼠, 大鼠, Cow, 小鸡, 马, 豚鼠, 兔, 猴, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Splicing Factor Proline/glutamine-Ric (SFPQ) (AA 269-362) antibodySFPQ 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 6D7 unconjugated
anti-Splicing Factor Proline/glutamine-Ric (SFPQ) (Middle Region) antibodySFPQ 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 豚鼠, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- SFPQ Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
- 有效期
- 6 months
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- 抗原
- SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))
- 别名
- SFPQ (SFPQ 产品)
- 别名
- 1110004P21Rik antibody, 2810416M14Rik antibody, 5730453G22Rik antibody, 9030402K04Rik antibody, AU021830 antibody, D4Ertd314e antibody, Gm12940 antibody, OTTMUSG00000009329 antibody, PSF antibody, REP1 antibody, hm:zeh0027 antibody, wu:fa11h12 antibody, wu:fd10f03 antibody, zgc:85935 antibody, POMP100 antibody, splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) antibody, splicing factor proline/glutamine-rich antibody, splicing factor proline and glutamine rich antibody, Sfpq antibody, sfpq antibody, SFPQ antibody
- 背景
- DNA-and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as an heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing, in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1, in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer may be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends, in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Transcriptional repression is probably mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO/SF-1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity.
- 分子量
- 76149
- 基因ID
- 6421
- NCBI登录号
- NP_005057
- UniProt
- P23246
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