This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This SELK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the Central region of human SELK.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C,-20 °C
储存方法
SELK Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
有效期
6 months
Fredericks, Hoffmann, Rose, Osterheld, Hess, Mercier, Hoffmann: "Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 46, pp. 16478-83, (2014) (PubMed).
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant.