This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This UNC5D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 483-511 amino acids from the Central region of human UNC5D.
UNC5D is receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).