MBD2 抗体
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- 抗原 See all MBD2 抗体
- MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MBD2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant protein of human MBD2
- 亚型
- IgG
- Top Product
- Discover our top product MBD2 Primary Antibody
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- 应用备注
- WB 1:200 - 1:2000 IHC 1:50 - 1:200
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))
- 别名
- MBD2 (MBD2 产品)
- 别名
- MBD2 antibody, DMTase antibody, NY-CO-41 antibody, MBD2a antibody, wu:fa97f06 antibody, zgc:111862 antibody, methyl-CpG binding domain protein 2 antibody, methyl-CpG binding domain protein 2 S homeolog antibody, MBD2 antibody, Mbd2 antibody, mbd2 antibody, mbd2.S antibody
- 背景
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Synonyms: Demethylase,DMTase,MBD 2,Mbd2,MBD2,MBD2a,Methyl CpG binding domain protein 2,Methyl CpG binding protein MBD2,Methyl-CpG-binding domain protein 2,Methyl-CpG-binding protein MBD2,NY CO 41
Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.
- 分子量
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Observed_MW: 53kDa
Calculated_MW: 31kDa/43kDa
- 基因ID
- 8932
- UniProt
- Q9UBB5
- 途径
- Chromatin Binding
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