This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This TLE4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-196 amino acids from the N-terminal region of human TLE4.
TLE4 is a transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).