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PLOD1 抗体 (N-Term)

PLOD1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB30211 unconjugated
产品编号 ABIN656585
发货至: 中国
  • 抗原 See all PLOD1 抗体
    PLOD1 (Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 1 (PLOD1))
    抗原表位
    • 7
    • 7
    • 7
    • 1
    • 1
    • 1
    • 1
    AA 66-94, N-Term
    适用
    • 20
    • 2
    宿主
    • 18
    • 3
    克隆类型
    • 19
    • 2
    多克隆
    标记
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    This PLOD1 antibody is un-conjugated
    应用范围
    • 20
    • 15
    • 13
    • 13
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    预测反应
    M
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This PLOD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human PLOD1.
    克隆位点
    RB30211
    亚型
    Ig Fraction
  • 应用备注
    WB: 1:1000. WB: 1:1000. WB: 1:1000-1:2000. WB: 1:2000. IHC-P: 1:25. IHC-P: 1:10~50. FC: 1:25
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    PLOD1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
    有效期
    6 months
  • Lindert, Cabral, Ausavarat, Tongkobpetch, Ludin, Barnes, Yeetong, Weis, Krabichler, Srichomthong, Makareeva, Janecke, Leikin, Röthlisberger, Rohrbach, Kennerknecht, Eyre, Suphapeetiporn, Giunta et al.: "MBTPS2 mutations cause defective regulated intramembrane proteolysis in X-linked osteogenesis imperfecta. ..." in: Nature communications, Vol. 7, pp. 11920, (2018) (PubMed).

    Cabral, Ishikawa, Garten, Makareeva, Sargent, Weis, Barnes, Webb, Shaw, Ala-Kokko, Lacbawan, Högler, Leikin, Blank, Zimmerberg, Eyre, Yamada, Marini: "Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta." in: PLoS genetics, Vol. 12, Issue 7, pp. e1006156, (2016) (PubMed).

    Wågsäter, Paloschi, Hanemaaijer, Hultenby, Bank, Franco-Cereceda, Lindeman, Eriksson: "Impaired collagen biosynthesis and cross-linking in aorta of patients with bicuspid aortic valve." in: Journal of the American Heart Association, Vol. 2, Issue 1, pp. e000034, (2013) (PubMed).

  • 抗原
    PLOD1 (Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 1 (PLOD1))
    别名
    PLOD1 (PLOD1 产品)
    别名
    EDS6 antibody, LH antibody, LH1 antibody, LLH antibody, PLOD antibody, Plod antibody, procollagen-lysine antibody, 2410042F05Rik antibody, AI854890 antibody, AV007929 antibody, Lh1 antibody, plod1 antibody, ik:tdsubs_rzpd609-29b19 antibody, plod antibody, wu:fc29c10 antibody, wu:fc95g08 antibody, wu:fi18a05 antibody, zgc:152876 antibody, procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 antibody, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 antibody, procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 antibody, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 L homeolog antibody, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1a antibody, PLOD1 antibody, Plod1 antibody, PLOD3 antibody, plod1.L antibody, plod1a antibody
    背景
    Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity.
    分子量
    83550
    基因ID
    5351
    NCBI登录号
    NP_000293
    UniProt
    Q02809
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