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PDP 抗体 (AA 308-336)

PDP 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB31327 unconjugated
产品编号 ABIN656386
发货至: 中国
  • 抗原 See all PDP 抗体
    PDP (Pyruvate Dehydrogenase Phosphatase (PDP))
    抗原表位
    • 15
    • 7
    • 7
    • 7
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 308-336
    适用
    • 52
    • 13
    • 10
    • 1
    人, 大鼠
    宿主
    • 50
    • 1
    • 1
    克隆类型
    • 51
    • 1
    多克隆
    标记
    • 17
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PDP antibody is un-conjugated
    应用范围
    • 38
    • 21
    • 18
    • 13
    • 13
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This PDP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDP1.
    克隆位点
    RB31327
    亚型
    Ig Fraction
    Top Product
    Discover our top product PDP Primary Antibody
  • 应用备注
    WB: 1:1000. WB: 1:2000. IHC-P: 1:10~50
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    PDP1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
    有效期
    6 months
  • Shan, Kang, Elf, Xie, Gu, Aguiar, Lonning, Hitosugi, Chung, Arellano, Khoury, Shin, Khuri, Boggon, Fan: "Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth." in: The Journal of biological chemistry, Vol. 289, Issue 31, pp. 21413-22, (2014) (PubMed).

  • 抗原
    PDP (Pyruvate Dehydrogenase Phosphatase (PDP))
    别名
    PDP1 (PDP 产品)
    别名
    153332_at antibody, CG12151 antibody, Dmel\\CG12151 antibody, PDP antibody, pdp antibody, PDH antibody, PDPC antibody, PPM2C antibody, Gm1024 antibody, Ppm2c antibody, im:7157162 antibody, zgc:174908 antibody, pdp1 antibody, ppm2c antibody, Pyruvate dehydrogenase phosphatase antibody, pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial antibody, pyruvate dehyrogenase phosphatase catalytic subunit 1 antibody, pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog antibody, Pdp antibody, LOC413080 antibody, PDP1 antibody, Pdp1 antibody, pdp1 antibody, pdp1.L antibody
    背景
    Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported, one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
    分子量
    61054
    基因ID
    54704
    NCBI登录号
    NP_001155251, NP_001155252, NP_001155253, NP_060914
    UniProt
    Q9P0J1
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