This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This POU6F2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-61 amino acids from the N-terminal region of human POU6F2.
RPF-1 antibody, WT5 antibody, WTSL antibody, D130006K24Rik antibody, si:ch211-124o16.3 antibody, POU class 6 homeobox 2 antibody, POU domain, class 6, transcription factor 2 antibody, POU6F2 antibody, Pou6f2 antibody, LOC483249 antibody, pou6f2 antibody
背景
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.