This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This JAG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1122-1150 amino acids from the C-terminal region of human JAG1.
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.