This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This FOXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-378 amino acids from the Central region of human FOXN1.
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq].