Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
预测反应
B, E, C, Zf, D, M, Rb, X, Rat, Sh
纯化方法
This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This H2AFZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-86 amino acids from the C-terminal region of human H2AFZ.
H2A.Z-1 antibody, H2A.z antibody, H2A/z antibody, H2AZ antibody, H2A.Z antibody, H2a.z-1 antibody, H2AFV antibody, H2Az antibody, XH2AZ antibody, h2a.zl1 antibody, h2a.zl2 antibody, H2A histone family member Z antibody, H2A histone family, member Z antibody, H2A histone family member Z L homeolog antibody, histone H2A.Z antibody, H2AFZ antibody, H2afz antibody, h2afz.L antibody
背景
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq].