LIN28A 抗体 (AA 108-138)
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- 抗原 See all LIN28A 抗体
- LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
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抗原表位
- AA 108-138
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LIN28A antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This LIN28A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-138 amino acids from the Central region of human LIN28A.
- 克隆位点
- RB14827
- 亚型
- Ig Fraction
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anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (N-Term) antibody
LIN28A 适用: 人, Pig, Cow, 犬, 绵羊 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 93-209) antibodyLIN28A 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 6D1F9 unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 108-138) antibodyLIN28A 适用: 人, 小鼠 WB, ELISA, IF, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 1-209) antibodyLIN28A 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 168-198), (C-Term) antibodyLIN28A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB14266 unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 177-210), (C-Term) antibodyLIN28A 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB51168 unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (C-Term) antibodyLIN28A 适用: 人, 小鼠 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 1-209) antibodyLIN28A 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 1-209) antibodyLIN28A 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 142-209) antibodyLIN28A 适用: 人 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- IF: 1:10~50. IF: 1:100. WB: 1:1000. WB: 1:4000. IHC-P: 1:50~100. FC: 1:10~50
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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- 抗原
- LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
- 别名
- LIN28A (LIN28A 产品)
- 别名
- CSDD1 antibody, LIN-28 antibody, LIN28 antibody, ZCCHC1 antibody, lin-28A antibody, AL024421 antibody, ENSMUSG00000070700 antibody, Gm10299 antibody, Lin-28 antibody, Lin28 antibody, Tex17 antibody, csdd1 antibody, lin-28 antibody, lin28 antibody, zcchc1 antibody, sb:cb650 antibody, zgc:55584 antibody, RGD1566408 antibody, lin-28 homolog A antibody, lin-28 homolog A (C. elegans) antibody, lin-28 homolog A S homeolog antibody, LIN28A antibody, Lin28a antibody, lin28a.S antibody, lin28a antibody
- 背景
- Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.
- 分子量
- 22743
- 基因ID
- 79727
- NCBI登录号
- NP_078950
- UniProt
- Q9H9Z2
- 途径
- Stem Cell Maintenance
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