This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This IRF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-286 amino acids from the C-terminal region of human IRF1.
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.