This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This IBTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-613 amino acids from the Central region of human IBTK.
The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.