This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This SELPLG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 379-405 amino acids from the C-terminal region of human SELPLG.
SELPLG is the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. The organization of the SELPG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters.