This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This PARD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1329-1356 amino acids from the C-terminal region of human PARD3.
PARD proteins, which were first identified in C. elegans, are essential for asymmetric cell division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs, see MIM 606057) and GTPase-activating proteins (GAPs, see MIM 604980), interacts with a large set of effector proteins that typically contain a CDC42/RAC (MIM 602048)-interactive binding (CRIB) domain.