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DKC1 抗体 (AA 185-213)

Name: DKC1 抗体 (AA 185-213)
SKU: ABIN651670
Availability: OutOfStock

DKC1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB26907 unconjugated

DKC1 Antibody (Center) (ABIN651670 and ABIN2840353) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. (DKC1 抗体 (AA 185-213))

IHC (p)

Confocal immunofluorescent analysis of DKC1 Antibody (Center) (ABIN651670 and ABIN2840353) with 293 cell followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). (DKC1 抗体 (AA 185-213))

DKC1 Antibody (Center) (ABIN651670 and ABIN2840353) western blot analysis in mouse testis tissue lysates (35 μg/lane). (DKC1 抗体 (AA 185-213))

3 images

产品编号 ABIN651670

发货至: 中国

Datasheet as PDF

抗原 See all DKC1 抗体

DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))
抗原表位
15

10

6

6

6

6

3

2

2

2

2

2

1

1

1

1

1

1

1
AA 185-213
适用
72

33

26

3

3

3

3

3

2

2

2

1

1

1

1

1
人, 小鼠
宿主
70

3

1
兔
Compatible Secondaries
克隆类型
65

9
多克隆
标记
32

6

5

4

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This DKC1 antibody is un-conjugated
应用范围
54

26

25

23

14

14

12

9

6

3

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This DKC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-213 amino acids from the Central region of human DKC1.

克隆位点

RB26907

亚型

Ig Fraction

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anti-Dyskeratosis Congenita 1, Dyskerin (DKC1) (Internal Region) antibody
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anti-Dyskeratosis Congenita 1, Dyskerin (DKC1) (AA 298-465) antibody
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anti-Dyskeratosis Congenita 1, Dyskerin (DKC1) (AA 298-509) antibody
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anti-Dyskeratosis Congenita 1, Dyskerin (DKC1) antibody
DKC1 适用: 人, 小鼠, 兔, 猴 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated

应用备注

IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
抗原

DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

别名

DKC1 (DKC1 产品)

别名

CBF5 antibody, DKC antibody, DKCX antibody, NAP57 antibody, NOLA4 antibody, XAP101 antibody, dyskerin antibody, fv62a07 antibody, wu:fa28f10 antibody, wu:fc87a02 antibody, wu:fi24a05 antibody, wu:fv62a07 antibody, zgc:110395 antibody, DKC1 antibody, cbf5 antibody, dkc antibody, nap57 antibody, nola4 antibody, xap101 antibody, BC068171 antibody, Nap57 antibody, AtCBF5 antibody, AtNAP57 antibody, homologue of NAP57 antibody, dyskerin pseudouridine synthase 1 antibody, microRNA 664b antibody, dyskeratosis congenita 1, dyskerin antibody, dyskeratosis congenita 1, dyskerin L homeolog antibody, homologue of NAP57 antibody, DKC1 antibody, MIR664B antibody, dkc1 antibody, dkc1.L antibody, Dkc1 antibody, NAP57 antibody

背景

DKC1 is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases.

分子量

57674

基因ID

1736

NCBI登录号

NP_001354

UniProt

O60832

途径

Telomere Maintenance