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MECP2 抗体 (pSer423)

MECP2 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB29261 unconjugated
产品编号 ABIN650833
发货至: 中国
  • 抗原 See all MECP2 抗体
    MECP2 (Methyl CpG Binding Protein 2 (MECP2))
    抗原表位
    • 19
    • 11
    • 9
    • 8
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer423
    适用
    • 101
    • 40
    • 30
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    人, 大鼠
    宿主
    • 100
    • 7
    • 1
    克隆类型
    • 101
    • 7
    多克隆
    标记
    • 62
    • 10
    • 8
    • 8
    • 7
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MECP2 antibody is un-conjugated
    应用范围
    • 79
    • 64
    • 36
    • 30
    • 11
    • 10
    • 8
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    预测反应
    Pr, M
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This MeCP2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S423 of human MeCP2.
    克隆位点
    RB29261
    亚型
    IgG
    Top Product
    Discover our top product MECP2 Primary Antibody
  • 应用备注
    WB: 1:500. WB: 1:500. WB: 1:500. IHC-P-Leica: 1:500
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid freeze-thaw cycles.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    有效期
    6 months
  • Qiu, Sylwestrak, Lieberman, Zhang, Liu, Ghosh: "The Rett syndrome protein MeCP2 regulates synaptic scaling." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 3, pp. 989-94, (2012) (PubMed).

    Stansfield, Pilsner, Lu, Wright, Guilarte: "Dysregulation of BDNF-TrkB signaling in developing hippocampal neurons by Pb(2+): implications for an environmental basis of neurodevelopmental disorders." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 127, Issue 1, pp. 277-95, (2012) (PubMed).

  • 抗原
    MECP2 (Methyl CpG Binding Protein 2 (MECP2))
    别名
    MeCP2 (MECP2 产品)
    别名
    AUTSX3 antibody, MRX16 antibody, MRX79 antibody, MRXS13 antibody, MRXSL antibody, PPMX antibody, RS antibody, RTS antibody, RTT antibody, 1500041B07Rik antibody, BB130002 antibody, D630021H01Rik antibody, Mbd5 antibody, WBP10 antibody, wu:fk96a04 antibody, zgc:111857 antibody, methyl-CpG binding protein 2 antibody, methyl CpG binding protein 2 antibody, methyl-CpG binding protein 2 S homeolog antibody, MECP2 antibody, Mecp2 antibody, mecp2 antibody, mecp2.S antibody
    背景
    DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
    分子量
    52441
    基因ID
    4204
    NCBI登录号
    NP_001104262, NP_004983
    UniProt
    P51608
    途径
    Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane
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