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- 抗原 See all ATG5 抗体
- ATG5 (ATG5 Autophagy Related 5 (ATG5))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ATG5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is purified through a protein A column, followed by dialysis against PBS.
- 免疫原
- This ATG5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the full length of human ATG5.
- 克隆位点
- RB12327
- 亚型
- Ig Fraction
- Top Product
- Discover our top product ATG5 Primary Antibody
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- 应用备注
- IF: 1:200. WB: 1:1000. WB: 1:500. WB: 1:500. IHC-P: 1:10~50
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 6, pp. 2003-8, (2012) (PubMed).
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Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 6, pp. 2003-8, (2012) (PubMed).
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- 抗原
- ATG5 (ATG5 Autophagy Related 5 (ATG5))
- 别名
- APG5 (ATG5 产品)
- 别名
- APG5 antibody, APG5-LIKE antibody, APG5L antibody, ASP antibody, hAPG5 antibody, ATG5 antibody, CG1643 antibody, DmAtg5 antibody, Dmel\\CG1643 antibody, atg5 antibody, 2010107M05Rik antibody, 3110067M24Rik antibody, AW319544 antibody, Apg5l antibody, Atg5l antibody, C88337 antibody, Paddy antibody, apg5l antibody, zgc:100934 antibody, ATATG5 antibody, AUTOPHAGY 5 antibody, MKP11.20 antibody, MKP11_20 antibody, autophagy related 5 antibody, Autophagy-related 5 antibody, ATG5 autophagy related 5 homolog (S. cerevisiae) antibody, autophagy related 5 L homeolog antibody, similar to S. cerevisiae ATG5 (YPL149W) which nucleates preautophagosome formation as a conjugate with Atg12 antibody, autophagy protein Apg5 family antibody, ATG5 antibody, Atg5 antibody, atg5 antibody, atg5.L antibody, APG5 antibody
- 背景
- Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG5, required for autophagy, conjugates to ATG12 and associates with an isolation membrane to form a cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. APG5 may also play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.
- 分子量
- 32447
- 基因ID
- 9474
- NCBI登录号
- NP_004840
- UniProt
- Q9H1Y0
- 途径
- Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Autophagy
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