PTRH2 抗体 (AA 80-110)
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- 抗原 See all PTRH2 抗体
- PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))
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抗原表位
- AA 80-110
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PTRH2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This Bit1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-110 amino acids from the Central region of human Bit1.
- 克隆位点
- RB06095
- 亚型
- Ig Fraction
- Top Product
- Discover our top product PTRH2 Primary Antibody
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anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 40-179) antibody
PTRH2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 40-179) antibodyPTRH2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 26-55), (N-Term) antibodyPTRH2 适用: 人 WB 宿主: 兔 Polyclonal RB42733 unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 100-149) antibodyPTRH2 适用: 人, Cow, 犬, 豚鼠, 马, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (C-Term) antibodyPTRH2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) antibodyPTRH2 适用: 人, 小鼠, 大鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (N-Term) antibodyPTRH2 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (Middle Region) antibodyPTRH2 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000. IHC-P: 1:10~50
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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- 抗原
- PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))
- 别名
- Bit1 (PTRH2 产品)
- 别名
- BIT1 antibody, PTH2 antibody, A230072I16Rik antibody, Bit1 antibody, CGI-147 antibody, wu:fj09f02 antibody, zgc:109954 antibody, RGD1306819 antibody, peptidyl-tRNA hydrolase 2 antibody, ptrh2 antibody, CC1G_10259 antibody, ANI_1_1036184 antibody, AOR_1_2082154 antibody, PTRH2 antibody, Ptrh2 antibody
- 背景
- Adhesion to extracellular matrix regulates cell survival via integrin engagement and cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. A role for Bit1 (Bcl-2 inhibitor of transcription 1) has been identified in this process. Bit1 is a mitochondrial protein released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis. AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. Bit1-AES complexes may switch off a survival-promoting gene transcription program controlled by TLE. Apoptosis of Bit1/AES transfected cells is inhibited when cells are permitted to attach to fibronectin through the alpha-beta integrin, suggesting that the contribution of the Bit1-AES pathway to anoikis is regulated by integrins.
- 分子量
- 19194
- 基因ID
- 51651
- NCBI登录号
- NP_057161
- UniProt
- Q9Y3E5
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