RGD1310562 antibody, NEIL3 antibody, zgc:103553 antibody, neil3 antibody, MAC12.12 antibody, MAC12_12 antibody, FGP2 antibody, FPG2 antibody, NEI3 antibody, hFPG2 antibody, hNEI3 antibody, AI449477 antibody, BC034753 antibody, C85903 antibody, nei-like DNA glycosylase 3 antibody, nei like DNA glycosylase 3 antibody, GRF zinc finger / Zinc knuckle protein antibody, nei-like DNA glycosylase 3 L homeolog antibody, nei like 3 (E. coli) antibody, Neil3 antibody, NEIL3 antibody, neil3 antibody, AT5G13920 antibody, neil3.L antibody
背景
Endonuclease VIII-like 1 (NEI1) is an enzyme that in humans is encoded by the NEIL1 gene. NEI1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.