Plant homeodomain (PHD) finger protein 2 (PHF2) is a putative transcription factor. PHF2 contains a zinc finger-like PHD domain that is distinct from other classes of zinc finger motifs and is often found in proteins that influence chromatin structure. It also contains a Jumonji C (JmjC) domain, which may play a role in histone demethylation. The PHF2 gene is ubiquitously expressed in adult mouse tissues, however, the majority of PHF2 expression in the mouse embryo occurs in the neural tube and root ganglia. PHF2 mutations have been associated with both early- and late-onset breast carcinoma.