TSH receptor 抗体
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- 抗原 See all TSH receptor (TSHR) 抗体
- TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TSH receptor antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
- 原理
- Mouse anti-Human Thyroid Stimulating Hormone Receptor / TSHR Antibody (beta chain) [Sodium Azide Free]
- 特异性
- Cytoplasmic, cell surface
- 纯化方法
- Recombinant human TSHR beta chain protein was used as the immunogen for this TSH Receptor antibody.
- 免疫原
- Recombinant human TSHR beta chain protein was used as the immunogen for this TSH Receptor antibody.
- Top Product
- Discover our top product TSHR Primary Antibody
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- 应用备注
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FACS: 0.5-1 μg/10^6 cells in 0.1ml
IF: 1-2 μg/mL
IHC (FFPE): 1-2 μg/mL for 30 min at RT - 限制
- 仅限研究用
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- 缓冲液
- In 1X PBS, BSA free, sodium azide free
- 储存液
- Azide free
- 储存条件
- 4 °C,-20 °C
- 储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- 抗原
- TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))
- 别名
- Thyrotropin receptor (TSHR 产品)
- 别名
- CHNG1 antibody, LGR3 antibody, hTSHR-I antibody, AI481368 antibody, hypothroid antibody, hyt antibody, pet antibody, TSHRA antibody, TSH-R antibody, thyroid stimulating hormone receptor antibody, tshr antibody, TSHR antibody, Tshr antibody
- 背景
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Target Description: Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.
Gene Symbol: TSHR///LGR3
- 基因ID
- 7253
- UniProt
- P16473
- 途径
- Thyroid Hormone Synthesis
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