ANO1 抗体
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- 抗原 See all ANO1 抗体
- ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This ANO1 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC)
- 原理
- Mouse anti-Human TMEM16A Antibody (DOG1) [IHC only]
- 特异性
- Cell Surface and Cytoplasmic
- 纯化方法
- Recombinant human TMEM16A/DOG1 protein was used as the immunogen for this TMEM16A antibody.
- 免疫原
- Recombinant human TMEM16A/DOG1 protein was used as the immunogen for this TMEM16A antibody.
- Top Product
- Discover our top product ANO1 Primary Antibody
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- 应用备注
- Prediluted format : incubate for 30 min at RT (2)
- 限制
- 仅限研究用
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- 缓冲液
- Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- 抗原
- ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
- 别名
- Anoctamin-1 (ANO1 产品)
- 别名
- DOG1 antibody, ORAOV2 antibody, TAOS2 antibody, TMEM16A antibody, Tmem16a antibody, anoctamin 1 antibody, anoctamin 1, calcium activated chloride channel antibody, Ano1 antibody, ANO1 antibody
- 背景
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Target Description: Expression of TMEM16A (DOG1) protein is elevated in the gastrointestinal stromal tumors (GIST 's), c-kit signaling-driven mesenchymal tumors of the GI tract. It is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for TMEM16A has been reported in 97.8 percent of scorable GIST 's, including all c-kit negative GIST 's. Overexpression has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha (PDGFR alpha) mutants that fail to express c-kit antigen. The overall sensitivity of TMEM16A and c-kit in GIST 's is nearly identical: 94.4 % vs. 94.7 %.
Gene Symbol: ANO1///DOG1///ORAOV2///TAOS2///TMEM16A
- 基因ID
- 55107
- UniProt
- Q5XXA6
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