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PRMT5 抗体 (N-Term)

PRMT5 适用: 人, 小鼠, 大鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN629605
发货至: 中国
  • 抗原 See all PRMT5 抗体
    PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))
    抗原表位
    • 15
    • 9
    • 8
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 87
    • 37
    • 19
    • 7
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    人, 小鼠, 大鼠, 犬
    宿主
    • 78
    • 6
    • 2
    • 1
    克隆类型
    • 67
    • 19
    • 1
    多克隆
    标记
    • 50
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PRMT5 antibody is un-conjugated
    应用范围
    • 56
    • 30
    • 27
    • 14
    • 14
    • 14
    • 13
    • 9
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    特异性
    PRMT5 antibody was raised against the N terminal of PRMT5
    纯化方法
    Purified
    免疫原
    PRMT5 antibody was raised using the N terminal of PRMT5 corresponding to a region with amino acids FDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLS
    Top Product
    Discover our top product PRMT5 Primary Antibody
  • 应用备注
    WB: 2.5 µg/mL, IHC: 4-8 µg/mL
    Optimal conditions should be determined by the investigator.
    说明

    PRMT5 Blocking Peptide, catalog no. 33R-2864, is also available for use as a blocking control in assays to test for specificity of this PRMT5 antibody

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Lyophilized powder. Add distilled water for a 1 mg/mL concentration of PRMT5 antibody in PBS
    浓度
    Lot specific
    缓冲液
    PBS
    注意事项
    Avoid repeated freeze/thaw cycles.
    Dilute only prior to immediate use.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
  • 抗原
    PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))
    别名
    PRMT5 (PRMT5 产品)
    背景
    PRMT5 methylates specific arginine residues in the small nuclear ribonucleoproteins Sm D1 and Sm D3 to monomethylarginine and to symmetrical dimethylarginines (sDMAs). It methylates SUPT5H. PRMT5 plays a role in the assembly of snRNP core particles and may play a role in cytokine-activated transduction pathways. It negatively regulates cyclin E1 promoter activity and cellular proliferation and May regulate the SUPT5H transcriptional elongation properties. It may be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. PRMT5 methylates histone H2A/H4 'Arg-3' during germ cell development and methylates histone H3 'Arg-8', which may repress transcription.
    分子量
    68 kDa (MW of target protein)
    途径
    Chromatin Binding, Regulation of Muscle Cell Differentiation, Ribonucleoprotein Complex Subunit Organization, Skeletal Muscle Fiber Development
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