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WNK1 抗体 (N-Term)

WNK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6266031
发货至: 中国
  • 抗原 See all WNK1 抗体
    WNK1 (WNK Lysine Deficient Protein Kinase 1 (WNK1))
    抗原表位
    • 15
    • 12
    • 7
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 69
    • 42
    • 39
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 84
    克隆类型
    • 76
    • 8
    多克隆
    标记
    • 31
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This WNK1 antibody is un-conjugated
    应用范围
    • 29
    • 28
    • 19
    • 13
    • 13
    • 12
    • 5
    • 4
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    WNK1 Antibody detects endogenous levels of total WNK1.
    预测反应
    Pig,Bovine,Sheep,Rabbit,Dog,Chicken
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human WNK1, corresponding to a region within N-terminal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product WNK1 Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    WNK1 (WNK Lysine Deficient Protein Kinase 1 (WNK1))
    别名
    WNK1 (WNK1 产品)
    别名
    HSAN2 antibody, HSN2 antibody, KDP antibody, PRKWNK1 antibody, PSK antibody, p65 antibody, WNK1 antibody, kdp antibody, psk antibody, hsn2 antibody, hsan2 antibody, pha2c antibody, prkwnk1 antibody, 6430573H23Rik antibody, EG406236 antibody, Hsn2 antibody, Prkwnk1 antibody, mKIAA0344 antibody, ATWNK1 antibody, T9J14.14 antibody, T9J14_14 antibody, ZIK4 antibody, with no lysine (K) kinase 1 antibody, WNK lysine deficient protein kinase 1 antibody, WNK lysine deficient protein kinase 1 L homeolog antibody, serine/threonine-protein kinase WNK1 antibody, with no lysine (K) kinase 1 antibody, WNK1 antibody, wnk1.L antibody, wnk1 antibody, LOC100056745 antibody, Wnk1 antibody
    背景

    Description: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).

    Gene: WNK1

    分子量
    230kDa
    基因ID
    65125
    UniProt
    Q9H4A3
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